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10.1100/2012/572514

http://scihub22266oqcxt.onion/10.1100/2012/572514
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22701362!3373183!22701362
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suck abstract from ncbi

pmid22701362      ScientificWorldJournal 2012 ; 2012 (?): 572514
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  • Effect of magnesium supplementation on the distribution patterns of zinc, copper, and magnesium in rabbits exposed to prolonged cadmium intoxication #MMPMID22701362
  • Bulat Z; Dukic-Cosic D; Antonijevic B; Bulat P; Vujanovic D; Buha A; Matovic V
  • ScientificWorldJournal 2012[]; 2012 (?): 572514 PMID22701362show ga
  • The present study is designed to investigate whether magnesium (Mg) supplementation may prevent Cd-induced alterations in zinc (Zn), copper (Cu), and magnesium (Mg) status in rabbits. For this purpose, the concentrations of Zn, Cu, and Mg were estimated in blood, urine, and organs (brain, heart, lungs, liver, kidney, spleen, pancreas, skeletal muscle, and bone) of rabbits given Cd (10 mg/kg b.w.) and rabbits cotreated with Mg (40 mg/kg b.w.) orally, as aqueous solutions of Cd chloride and Mg acetate every day for 4 weeks. Samples were mineralized with conc. HNO(3) and HClO(4) (4:1) and metals concentrations were determined by atomic absorption spectrophotometry (AAS). Magnesium supplementation succeeded to overcome Cd-induced disbalance of investigated bioelements. Beneficial effects of Mg were observed on Zn levels in blood and urine, on Cu levels in urine, and on Mg levels in blood. Magnesium pretreatment also managed to counteract or reduce all Cd-induced changes in levels of Cu and Mg in organs, while it did not exert this effect on Zn levels. These findings suggest that enhanced dietary Mg intake during Cd exposure can have at least partly beneficial effect on Cd-induced alterations in homeostasis of zinc, copper, and magnesium.
  • |*Dietary Supplements[MESH]
  • |Administration, Oral[MESH]
  • |Animals[MESH]
  • |Cadmium/*toxicity[MESH]
  • |Copper/*metabolism[MESH]
  • |Magnesium/*administration & dosage/*blood[MESH]
  • |Metabolic Clearance Rate/drug effects[MESH]
  • |Organ Specificity/drug effects[MESH]
  • |Rabbits[MESH]
  • |Tissue Distribution/*drug effects[MESH]
  • |Treatment Outcome[MESH]


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