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10.1038/nrd3699 http://scihub22266oqcxt.onion/10.1038/nrd3699 22679642!ä!22679642 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Drug+Discov 2012 ; 11 (5): 367-83 Nephropedia Template TP {{tp|p=22679642|t=2012. The biology and therapeutic targeting of the proprotein convertases |pdf=|usr=}}{{22679642}} gab.com Text The biology and therapeutic targeting of the proprotein convertases JO: Nat Rev Drug Discov http://www.kidney.de/pget.php?&tw=1&pmid=22679642 #FOAvip The mammalian proprotein convertases constitute a family of nine secretory serine proteases that are related to bacterial subtilisin and yeast kexin. Seven of these (proprotein convertase 1 (PC1), PC2, furin, PC4, PC5, paired basic amino acid cleaving enzyme 4 (PACE4) and PC7) activate cellular and pathogenic precursor proteins by cleavage at single or paired basic residues, whereas subtilisin kexin isozyme 1 (SKI-1) and proprotein convertase subtilisin kexin 9 (PCSK9) regulate cholesterol and/or lipid homeostasis via cleavage at non-basic residues or through induced degradation of receptors. Proprotein convertases are now considered to be attractive targets for the development of powerful novel therapeutics. In this Review, we summarize the physiological functions and pathological implications of the proprotein convertases, and discuss proposed strategies to control some of their activities, including their therapeutic application and validation in selected disease states. Twit Text FOAVip The biology and therapeutic targeting of the proprotein convertases ????Nat Rev Drug Discov http://www.kidney.de/pget.php?&tw=1&pmid=22679642 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22679642 #FOAvip English Wikipedia <ref>{{Cite pmid|22679642}}</ref> The biology and therapeutic targeting of the proprotein convertases #MMPMID22679642 Seidah NG; Prat A Nat Rev Drug Discov 2012[May]; 11 (5): 367-83 PMID22679642show ga The mammalian proprotein convertases constitute a family of nine secretory serine proteases that are related to bacterial subtilisin and yeast kexin. Seven of these (proprotein convertase 1 (PC1), PC2, furin, PC4, PC5, paired basic amino acid cleaving enzyme 4 (PACE4) and PC7) activate cellular and pathogenic precursor proteins by cleavage at single or paired basic residues, whereas subtilisin kexin isozyme 1 (SKI-1) and proprotein convertase subtilisin kexin 9 (PCSK9) regulate cholesterol and/or lipid homeostasis via cleavage at non-basic residues or through induced degradation of receptors. Proprotein convertases are now considered to be attractive targets for the development of powerful novel therapeutics. In this Review, we summarize the physiological functions and pathological implications of the proprotein convertases, and discuss proposed strategies to control some of their activities, including their therapeutic application and validation in selected disease states. |*Drug Delivery Systems[MESH] |*Drug Design[MESH] |Animals[MESH] |Cholesterol/metabolism[MESH] |Homeostasis/physiology[MESH] |Humans[MESH] |Lipid Metabolism/physiology[MESH] |Proprotein Convertases/drug effects/*metabolism[MESH]The biology and therapeutic targeting of the proprotein convertases (epmc).pdf DeepDyve Pubget Overpricing