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10.1055/s-0031-1298620 http://scihub22266oqcxt.onion/10.1055/s-0031-1298620 22648377!ä!22648377 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Planta+Med 2012 ; 78 (10): 968-73 Nephropedia Template TP {{tp|p=22648377|t=2012. The protective effect of 3-deoxysappanchalcone on in vitro influenza virus-induced apoptosis and inflammation |pdf=|usr=}}{{22648377}} gab.com Text The protective effect of 3-deoxysappanchalcone on in vitro influenza virus-induced apoptosis and inflammation JO: Planta Med http://www.kidney.de/pget.php?&tw=1&pmid=22648377 #FOAvip Influenza virus is one of the most important causes of acute respiratory disease. Viral infection and viral replication activate multiple cell signalling pathways. Apoptosis of infected cells and immune response against viral replication, which are generally considered to be protective mechanisms, are also probably mediated by viruses, which lead to severe health problems. We previously reported that 3-deoxysappanchalcone (3-DSC), a compound that is isolated from Caesalpinia sappan, exhibited in vitro anti-influenza activity. In the present study, we further identified that 3-DSC inhibited viral genomic replication and transcription only at a relatively high concentration. We then evaluated the effect of 3-DSC on the regulation of virus-induced cellular apoptosis. 3-DSC ameliorated virus-induced DNA fragmentation in a concentration-dependent manner, which tends to be a consequence of its inhibition of upstream caspase activation. 3-DSC also protected host cells against influenza-induced inflammation by suppressing CCL5 and CXCL10 secretions in endothelial cells and reducing the production of IL-6 and IL-1beta in monocytes/macrophages. In conclusion, our results demonstrate that anti-influenza virus mechanisms of 3-DSC involved anti-apoptosis and anti-inflammation activities in vitro. Moreover, 3-DSC could be a promising drug candidate for influenza treatment. Twit Text FOAVip The protective effect of 3-deoxysappanchalcone on in vitro influenza virus-induced apoptosis and inflammation ????Planta Med http://www.kidney.de/pget.php?&tw=1&pmid=22648377 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22648377 #FOAvip English Wikipedia <ref>{{Cite pmid|22648377}}</ref> The protective effect of 3-deoxysappanchalcone on in vitro influenza virus-induced apoptosis and inflammation #MMPMID22648377 Yang F; Zhou WL; Liu AL; Qin HL; Lee SM; Wang YT; Du GH Planta Med 2012[Jun]; 78 (10): 968-73 PMID22648377show ga Influenza virus is one of the most important causes of acute respiratory disease. Viral infection and viral replication activate multiple cell signalling pathways. Apoptosis of infected cells and immune response against viral replication, which are generally considered to be protective mechanisms, are also probably mediated by viruses, which lead to severe health problems. We previously reported that 3-deoxysappanchalcone (3-DSC), a compound that is isolated from Caesalpinia sappan, exhibited in vitro anti-influenza activity. In the present study, we further identified that 3-DSC inhibited viral genomic replication and transcription only at a relatively high concentration. We then evaluated the effect of 3-DSC on the regulation of virus-induced cellular apoptosis. 3-DSC ameliorated virus-induced DNA fragmentation in a concentration-dependent manner, which tends to be a consequence of its inhibition of upstream caspase activation. 3-DSC also protected host cells against influenza-induced inflammation by suppressing CCL5 and CXCL10 secretions in endothelial cells and reducing the production of IL-6 and IL-1beta in monocytes/macrophages. In conclusion, our results demonstrate that anti-influenza virus mechanisms of 3-DSC involved anti-apoptosis and anti-inflammation activities in vitro. Moreover, 3-DSC could be a promising drug candidate for influenza treatment. |*Apoptosis[MESH] |*Cytoprotection[MESH] |Animals[MESH] |Anti-Inflammatory Agents, Non-Steroidal/chemistry/pharmacology[MESH] |Antiviral Agents/chemistry/pharmacology[MESH] |Caesalpinia/chemistry[MESH] |Caspases/drug effects[MESH] |Cell Line, Tumor[MESH] |Chalcones/chemistry/*pharmacology[MESH] |Chemokine CCL5/chemistry[MESH] |Chemokine CXCL10/chemistry[MESH] |DNA Fragmentation/drug effects[MESH] |Dogs[MESH] |Dose-Response Relationship, Drug[MESH] |Drug Evaluation, Preclinical[MESH] |Enzyme Activation[MESH] |Genome, Viral/drug effects[MESH] |Humans[MESH] |Inflammation/*virology[MESH] |Influenza A Virus, H1N1 Subtype/genetics/*pathogenicity/physiology[MESH] |Transcription, Genetic/drug effects[MESH]The protective effect of 3-deoxysappanchalcone on in vitro influenza (epmc).pdf DeepDyve Pubget Overpricing