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10.1016/j.cell.2012.03.042 http://scihub22266oqcxt.onion/10.1016/j.cell.2012.03.042 22632970!3367386!22632970     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2012 ; 149 (5): 1060-72 Nephropedia Template TP {{tp|p=22632970|t=2012. Ferroptosis: an iron-dependent form of nonapoptotic cell death |pdf=|usr=}}{{22632970}} gab.com Text Ferroptosis: an iron-dependent form of nonapoptotic cell death JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=22632970 #FOAvip Nonapoptotic forms of cell death may facilitate the selective elimination of some tumor cells or be activated in specific pathological states. The oncogenic RAS-selective lethal small molecule erastin triggers a unique iron-dependent form of nonapoptotic cell death that we term ferroptosis. Ferroptosis is dependent upon intracellular iron, but not other metals, and is morphologically, biochemically, and genetically distinct from apoptosis, necrosis, and autophagy. We identify the small molecule ferrostatin-1 as a potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices, suggesting similarities between these two processes. Indeed, erastin, like glutamate, inhibits cystine uptake by the cystine/glutamate antiporter (system x(c)(-)), creating a void in the antioxidant defenses of the cell and ultimately leading to iron-dependent, oxidative death. Thus, activation of ferroptosis results in the nonapoptotic destruction of certain cancer cells, whereas inhibition of this process may protect organisms from neurodegeneration. Twit Text FOAVip Ferroptosis: an iron-dependent form of nonapoptotic cell death ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=22632970 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22632970 #FOAvip English Wikipedia <ref>{{Cite pmid|22632970}}</ref> Ferroptosis: an iron-dependent form of nonapoptotic cell death #MMPMID22632970 Dixon SJ; Lemberg KM; Lamprecht MR; Skouta R; Zaitsev EM; Gleason CE; Patel DN; Bauer AJ; Cantley AM; Yang WS; Morrison B 3rd; Stockwell BR Cell 2012[May]; 149 (5): 1060-72 PMID22632970show ga Nonapoptotic forms of cell death may facilitate the selective elimination of some tumor cells or be activated in specific pathological states. The oncogenic RAS-selective lethal small molecule erastin triggers a unique iron-dependent form of nonapoptotic cell death that we term ferroptosis. Ferroptosis is dependent upon intracellular iron, but not other metals, and is morphologically, biochemically, and genetically distinct from apoptosis, necrosis, and autophagy. We identify the small molecule ferrostatin-1 as a potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices, suggesting similarities between these two processes. Indeed, erastin, like glutamate, inhibits cystine uptake by the cystine/glutamate antiporter (system x(c)(-)), creating a void in the antioxidant defenses of the cell and ultimately leading to iron-dependent, oxidative death. Thus, activation of ferroptosis results in the nonapoptotic destruction of certain cancer cells, whereas inhibition of this process may protect organisms from neurodegeneration. |*Cell Death/drug effects[MESH] |Animals[MESH] |Cyclohexylamines/pharmacology[MESH] |Fibroblasts/cytology/metabolism[MESH] |Glutamic Acid/metabolism[MESH] |Hippocampus/cytology[MESH] |Humans[MESH] |In Vitro Techniques[MESH] |Iron/*metabolism[MESH] |Lipid Metabolism[MESH] |Neoplasms/pathology[MESH] |Phenylenediamines/pharmacology[MESH] |Piperazines/metabolism[MESH] |Rats[MESH]Ferroptosis: an iron-dependent form of nonapoptotic cell death (epmc).pdf DeepDyve Pubget Overpricing