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Markers of Borna disease virus infection in cats with staggering disease #MMPMID22553310
Wensman JJ; Jaderlund KH; Gustavsson MH; Hansson-Hamlin H; Karlstam E; Lilliehook I; Ostrom IL; Belak S; Berg M; Holst BS
J Feline Med Surg 2012[Aug]; 14 (8): 573-82 PMID22553310show ga
Borna disease virus (BDV) is a RNA-virus causing neurological disorders in a wide range of mammals. In cats, BDV infection may cause staggering disease. Presently, staggering disease is a tentative clinical diagnosis, only confirmed at necropsy. In this study, cats with staggering disease were investigated to study markers of BDV infection aiming for improvement of current diagnostics. Nineteen cats fulfilled the inclusion criteria based on neurological signs and pathological findings. In 17/19 cats, BDV infection markers (BDV-specific antibodies and/or BDV-RNA) were found, and antibodies in serum (13/16, 81%) were the most common marker. BDV-RNA was found in 11/19 cats (58%). In a reference population without neurological signs, 4/25 cats were seropositive (16%). The clinical history and neurological signs in combination with presence of BDV infection markers, where serology and rRT-PCR on blood can be helpful tools, improve the diagnostic accuracy in the living cat.
J+Feline+Med+Surg 2012 ; 14 (8): 573-82
