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10.1097/QAD.0b013e328354b43f http://scihub22266oqcxt.onion/10.1097/QAD.0b013e328354b43f 22526518!ä!22526518 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       AIDS 2012 ; 26 (12): F31-7 Nephropedia Template TP {{tp|p=22526518|t=2012. Chronic progressive HIV-1 infection is associated with elevated levels of myeloid-derived suppressor cells |pdf=|usr=}}{{22526518}} gab.com Text Chronic progressive HIV-1 infection is associated with elevated levels of myeloid-derived suppressor cells JO: AIDS http://www.kidney.de/pget.php?&tw=1&pmid=22526518 #FOAvip OBJECTIVES: Myeloid-derived suppressor cells (MDSCs) have been described as suppressors of T-cell functions in many tumor models. However, MDSC in HIV-1 infection have not been studied to date. As impaired T-cell function is a hallmark of chronic progressive HIV-1 infection, we hypothesized that MDSC also play a role here. METHODS: Surface staining and flow cytometry analysis were performed on freshly isolated peripheral blood mononuclear cells (PBMC) of HIV-infected individuals and compared to healthy controls and individuals with lung carcinoma. MDSC of late-stage HIV-infected individuals were isolated using magnetic beads and cocultured with the respective CD8 T cells for evaluation of proliferative capacity. RESULTS: We found that chronically HIV-infected HAART-naive individuals had significantly higher CD11bCD14CD33CD15 MDSC levels than healthy controls (P = 0.01). MDSC frequencies showed a positive correlation with viral load (r = 0.24, P = 0.0002) and a negative correlation with CD4 cell count (r = 0.29, P < 0.0001). Initiation of HAART led to a rapid drop in MDSC levels. MDSC from HIV-infected progressors restricted the proliferative capacity of CD8 T cells from healthy donors and of Gag/Nef-specific CD8 T cells from HIV-controllers in vitro. Furthermore, CD11bCD14CD33CD15 MDSC induced the expansion of CD4CD25FoxP3 regulatory T cells when coincubated with PBMC from controllers in vitro. CONCLUSION: We conclude that chronic uncontrolled HIV-infection is associated with elevated levels of MDSC, which potentially contribute to the impaired T-cell responses characteristic for the progressive disease stage. Twit Text FOAVip Chronic progressive HIV-1 infection is associated with elevated levels of myeloid-derived suppressor cells ????AIDS http://www.kidney.de/pget.php?&tw=1&pmid=22526518 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22526518 #FOAvip English Wikipedia <ref>{{Cite pmid|22526518}}</ref> Chronic progressive HIV-1 infection is associated with elevated levels of myeloid-derived suppressor cells #MMPMID22526518 Vollbrecht T; Stirner R; Tufman A; Roider J; Huber RM; Bogner JR; Lechner A; Bourquin C; Draenert R AIDS 2012[Jul]; 26 (12): F31-7 PMID22526518show ga OBJECTIVES: Myeloid-derived suppressor cells (MDSCs) have been described as suppressors of T-cell functions in many tumor models. However, MDSC in HIV-1 infection have not been studied to date. As impaired T-cell function is a hallmark of chronic progressive HIV-1 infection, we hypothesized that MDSC also play a role here. METHODS: Surface staining and flow cytometry analysis were performed on freshly isolated peripheral blood mononuclear cells (PBMC) of HIV-infected individuals and compared to healthy controls and individuals with lung carcinoma. MDSC of late-stage HIV-infected individuals were isolated using magnetic beads and cocultured with the respective CD8 T cells for evaluation of proliferative capacity. RESULTS: We found that chronically HIV-infected HAART-naive individuals had significantly higher CD11bCD14CD33CD15 MDSC levels than healthy controls (P = 0.01). MDSC frequencies showed a positive correlation with viral load (r = 0.24, P = 0.0002) and a negative correlation with CD4 cell count (r = 0.29, P < 0.0001). Initiation of HAART led to a rapid drop in MDSC levels. MDSC from HIV-infected progressors restricted the proliferative capacity of CD8 T cells from healthy donors and of Gag/Nef-specific CD8 T cells from HIV-controllers in vitro. Furthermore, CD11bCD14CD33CD15 MDSC induced the expansion of CD4CD25FoxP3 regulatory T cells when coincubated with PBMC from controllers in vitro. CONCLUSION: We conclude that chronic uncontrolled HIV-infection is associated with elevated levels of MDSC, which potentially contribute to the impaired T-cell responses characteristic for the progressive disease stage. |Antiretroviral Therapy, Highly Active[MESH] |CD8-Positive T-Lymphocytes/immunology[MESH] |Carcinoma, Non-Small-Cell Lung/immunology[MESH] |Case-Control Studies[MESH] |Flow Cytometry[MESH] |HIV Infections/drug therapy/*immunology[MESH] |HIV-1/*immunology[MESH] |Humans[MESH] |Leukocytes, Mononuclear/drug effects/*immunology[MESH] |Lung Neoplasms/immunology[MESH] |Myeloid Cells/drug effects/*immunology[MESH]Chronic progressive HIV-1 infection is associated with elevated levels(epmc).pdf DeepDyve Pubget Overpricing