Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1055/s-0031-1278257 http://scihub22266oqcxt.onion/10.1055/s-0031-1278257 22477300!2733022!22477300     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Angiol 2007 ; 16 (3): 92-7 Nephropedia Template TP {{tp|p=22477300|t=2007. Interaction between the heme oxygenase system and aldosterone in hypertension |pdf=|usr=}}{{22477300}} gab.com Text Interaction between the heme oxygenase system and aldosterone in hypertension JO: Int J Angiol http://www.kidney.de/pget.php?&tw=1&pmid=22477300 #FOAvip The chronic intraperitoneal administration of the heme oxygenase inducer, hemin (15 mg/kg daily), for three weeks reduced blood pressure in adult spontaneously hypertensive rats (SHR) from 210.1+/-1.03 mmHg to 127+/-0.9 mmHg (n=10, P<0.01) but had no effect on age-matched normotensive Wistar-Kyoto or Sprague-Dawley strains. The antihypertensive effect of hemin was accompanied by reduced expression of aldosterone synthase messenger RNA and depleted levels of plasma aldosterone (675.7+/-121.6 pg/mL versus 365.7+/-37 pg/mL; n=4, P<0.05).Because aldosterone is known to stimulate phospholipase C (PLC), the effect of hemin on PLC was examined. Hemin abated PLC activity (29.6+/-1.5 nmol/min/mL versus 3.1+/-0.9 nmol/min/mL; n=5, P<0.01) and this was accompanied by depleted levels of intracellular calcium (551+/-46 nM versus 103.2+/-6.3 nM; n=4, P<0.01) in the aorta of SHR. In contrast, enhanced heme oxygenase activity and elevated cyclic GMP levels (17.74+/-0.08 pmol/mg versus 30.4+/-2.3 pmol/mg protein; n=6, P<0.01) were detected in hemin-treated SHR. Additionally, hemin therapy also suppressed inflammatory and oxidative insults by significantly reducing nuclear factor kappa B messenger RNA expression while enhancing the total antioxidant capacity (0.22+/-0.02 Trolox equivalent antioxidant capacity (TEA C)/mg protein versus 0.60+/-0.04 TEA C/mg protein; n=4, P<0.01).The concomitant depletion of aldosterone, PLC activity, intracellular calcium and the corresponding decline of inflammatory and oxidative insults may account for the antihypertensive effects of hemin. Twit Text FOAVip Interaction between the heme oxygenase system and aldosterone in hypertension ????Int J Angiol http://www.kidney.de/pget.php?&tw=1&pmid=22477300 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22477300 #FOAvip English Wikipedia <ref>{{Cite pmid|22477300}}</ref> Interaction between the heme oxygenase system and aldosterone in hypertension #MMPMID22477300 Ndisang JF; Jadhav A; Lane N Int J Angiol 2007[Fal]; 16 (3): 92-7 PMID22477300show ga The chronic intraperitoneal administration of the heme oxygenase inducer, hemin (15 mg/kg daily), for three weeks reduced blood pressure in adult spontaneously hypertensive rats (SHR) from 210.1+/-1.03 mmHg to 127+/-0.9 mmHg (n=10, P<0.01) but had no effect on age-matched normotensive Wistar-Kyoto or Sprague-Dawley strains. The antihypertensive effect of hemin was accompanied by reduced expression of aldosterone synthase messenger RNA and depleted levels of plasma aldosterone (675.7+/-121.6 pg/mL versus 365.7+/-37 pg/mL; n=4, P<0.05).Because aldosterone is known to stimulate phospholipase C (PLC), the effect of hemin on PLC was examined. Hemin abated PLC activity (29.6+/-1.5 nmol/min/mL versus 3.1+/-0.9 nmol/min/mL; n=5, P<0.01) and this was accompanied by depleted levels of intracellular calcium (551+/-46 nM versus 103.2+/-6.3 nM; n=4, P<0.01) in the aorta of SHR. In contrast, enhanced heme oxygenase activity and elevated cyclic GMP levels (17.74+/-0.08 pmol/mg versus 30.4+/-2.3 pmol/mg protein; n=6, P<0.01) were detected in hemin-treated SHR. Additionally, hemin therapy also suppressed inflammatory and oxidative insults by significantly reducing nuclear factor kappa B messenger RNA expression while enhancing the total antioxidant capacity (0.22+/-0.02 Trolox equivalent antioxidant capacity (TEA C)/mg protein versus 0.60+/-0.04 TEA C/mg protein; n=4, P<0.01).The concomitant depletion of aldosterone, PLC activity, intracellular calcium and the corresponding decline of inflammatory and oxidative insults may account for the antihypertensive effects of hemin. äInteraction between the heme oxygenase system and aldosterone in hyper(epmc).pdf DeepDyve Pubget Overpricing