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10.1038/onc.2012.112 http://scihub22266oqcxt.onion/10.1038/onc.2012.112 22469976!ä!22469976 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncogene 2013 ; 32 (7): 849-60 Nephropedia Template TP {{tp|p=22469976|t=2013. Host-related carcinoembryonic antigen cell adhesion molecule 1 promotes metastasis of colorectal cancer |pdf=|usr=}}{{22469976}} gab.com Text Host-related carcinoembryonic antigen cell adhesion molecule 1 promotes metastasis of colorectal cancer JO: Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=22469976 #FOAvip Liver metastasis is the predominant cause of colorectal cancer (CRC)-related mortality in developed countries. Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a cell adhesion molecule with reduced expression in early phases of CRC development and thus functions as a tumor growth inhibitor. However, CEACAM1 is upregulated in metastatic colon cancer, suggesting a bimodal role in CRC progression. To investigate the role of this protein in the host metastatic environment, Ceacam1(-/-) mice were injected intrasplenically with metastatic MC38 mouse CRC cells. A significant reduction in metastatic burden was observed in Ceacam1(-/-) compared with wild-type (WT) livers. Intravital microscopy showed decreased early survival of MC38 cells in Ceacam1(-/-) endothelial environment. Metastatic cell proliferation within the Ceacam1(-/-) livers was also diminished. Bone marrow-derived cell recruitment, attenuation of immune infiltrates and diminished CCL2, CCL3 and CCL5 chemokine production participated in the reduced Ceacam1(-/-) metastatic phenotype. Transplantations of WT bone marrow (BM) into Ceacam1(-/-) mice fully rescued metastatic development, whereas Ceacam1(-/-) BM transfer into WT mice showed reduced metastatic burden. Chimeric immune cell profiling revealed diminished recruitment of CD11b(+)Gr1(+) myeloid-derived suppressor cells (MDSCs) to Ceacam1(-/-) metastatic livers and adoptive transfer of MDSCs confirmed the involvement of these immune cells in reduction of liver metastasis. CEACAM1 may represent a novel metastatic CRC target for treatment. Twit Text FOAVip Host-related carcinoembryonic antigen cell adhesion molecule 1 promotes metastasis of colorectal cancer ????Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=22469976 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22469976 #FOAvip English Wikipedia <ref>{{Cite pmid|22469976}}</ref> Host-related carcinoembryonic antigen cell adhesion molecule 1 promotes metastasis of colorectal cancer #MMPMID22469976 Arabzadeh A; Chan C; Nouvion AL; Breton V; Benlolo S; DeMarte L; Turbide C; Brodt P; Ferri L; Beauchemin N Oncogene 2013[Feb]; 32 (7): 849-60 PMID22469976show ga Liver metastasis is the predominant cause of colorectal cancer (CRC)-related mortality in developed countries. Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a cell adhesion molecule with reduced expression in early phases of CRC development and thus functions as a tumor growth inhibitor. However, CEACAM1 is upregulated in metastatic colon cancer, suggesting a bimodal role in CRC progression. To investigate the role of this protein in the host metastatic environment, Ceacam1(-/-) mice were injected intrasplenically with metastatic MC38 mouse CRC cells. A significant reduction in metastatic burden was observed in Ceacam1(-/-) compared with wild-type (WT) livers. Intravital microscopy showed decreased early survival of MC38 cells in Ceacam1(-/-) endothelial environment. Metastatic cell proliferation within the Ceacam1(-/-) livers was also diminished. Bone marrow-derived cell recruitment, attenuation of immune infiltrates and diminished CCL2, CCL3 and CCL5 chemokine production participated in the reduced Ceacam1(-/-) metastatic phenotype. Transplantations of WT bone marrow (BM) into Ceacam1(-/-) mice fully rescued metastatic development, whereas Ceacam1(-/-) BM transfer into WT mice showed reduced metastatic burden. Chimeric immune cell profiling revealed diminished recruitment of CD11b(+)Gr1(+) myeloid-derived suppressor cells (MDSCs) to Ceacam1(-/-) metastatic livers and adoptive transfer of MDSCs confirmed the involvement of these immune cells in reduction of liver metastasis. CEACAM1 may represent a novel metastatic CRC target for treatment. |Animals[MESH] |Carcinoembryonic Antigen/genetics/metabolism/*physiology[MESH] |Carcinoma/blood supply/genetics/*pathology[MESH] |Cell Proliferation[MESH] |Cell Survival[MESH] |Colorectal Neoplasms/blood supply/genetics/*pathology[MESH] |Liver/metabolism/pathology[MESH] |Mice[MESH] |Mice, Knockout[MESH] |Models, Biological[MESH] |Neoplasm Metastasis[MESH] |Neovascularization, Pathologic/genetics[MESH] |Organ Specificity/genetics[MESH]Host-related carcinoembryonic antigen cell adhesion molecule 1 promote(epmc).pdf DeepDyve Pubget Overpricing