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10.1016/j.virol.2012.01.037 http://scihub22266oqcxt.onion/10.1016/j.virol.2012.01.037 22365327!ä!22365327 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Virology 2012 ; 427 (1): 1-9 Nephropedia Template TP {{tp|p=22365327|t=2012. Avian influenza A virus PB2 promotes interferon type I inducing properties of a swine strain in porcine dendritic cells |pdf=|usr=}}{{22365327}} gab.com Text Avian influenza A virus PB2 promotes interferon type I inducing properties of a swine strain in porcine dendritic cells JO: Virology http://www.kidney.de/pget.php?&tw=1&pmid=22365327 #FOAvip The 2009 influenza A virus (IAV) pandemic resulted from reassortment of avian, human and swine strains probably in pigs. To elucidate the role of viral genes in host adaptation regarding innate immune responses, we focussed on the effect of genes from an avian H5N1 and a porcine H1N1 IAV on infectivity and activation of porcine GM-CSF-induced dendritic cells (DC). The highest interferon type I responses were achieved by the porcine virus reassortant containing the avian polymerase gene PB2. This finding was not due to differential tropism since all viruses infected DC equally. All viruses equally induced MHC class II, but porcine H1N1 expressing the avian viral PB2 induced more prominent nuclear NF-kappaB translocation compared to its parent IAV. The enhanced activation of DC may be detrimental or beneficial. An over-stimulation of innate responses could result in either pronounced tissue damage or increased resistance against IAV reassortants carrying avian PB2. Twit Text FOAVip Avian influenza A virus PB2 promotes interferon type I inducing properties of a swine strain in porcine dendritic cells ????Virology http://www.kidney.de/pget.php?&tw=1&pmid=22365327 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22365327 #FOAvip English Wikipedia <ref>{{Cite pmid|22365327}}</ref> Avian influenza A virus PB2 promotes interferon type I inducing properties of a swine strain in porcine dendritic cells #MMPMID22365327 Ocana-Macchi M; Ricklin ME; Python S; Monika GA; Stech J; Stech O; Summerfield A Virology 2012[May]; 427 (1): 1-9 PMID22365327show ga The 2009 influenza A virus (IAV) pandemic resulted from reassortment of avian, human and swine strains probably in pigs. To elucidate the role of viral genes in host adaptation regarding innate immune responses, we focussed on the effect of genes from an avian H5N1 and a porcine H1N1 IAV on infectivity and activation of porcine GM-CSF-induced dendritic cells (DC). The highest interferon type I responses were achieved by the porcine virus reassortant containing the avian polymerase gene PB2. This finding was not due to differential tropism since all viruses infected DC equally. All viruses equally induced MHC class II, but porcine H1N1 expressing the avian viral PB2 induced more prominent nuclear NF-kappaB translocation compared to its parent IAV. The enhanced activation of DC may be detrimental or beneficial. An over-stimulation of innate responses could result in either pronounced tissue damage or increased resistance against IAV reassortants carrying avian PB2. |*Host-Pathogen Interactions[MESH] |Animals[MESH] |Birds[MESH] |Cell Line[MESH] |Chick Embryo[MESH] |Dendritic Cells/immunology/*virology[MESH] |Dogs[MESH] |Genes, Viral[MESH] |Granulocyte-Macrophage Colony-Stimulating Factor/metabolism[MESH] |Humans[MESH] |Influenza A Virus, H1N1 Subtype/genetics/*immunology[MESH] |Influenza A Virus, H5N1 Subtype/genetics/*immunology[MESH] |Interferon Type I/*metabolism[MESH] |Major Histocompatibility Complex[MESH] |Mice[MESH] |NF-kappa B/metabolism[MESH] |Orthomyxoviridae Infections/*immunology/veterinary/virology[MESH] |Pandemics[MESH] |Promoter Regions, Genetic/genetics[MESH] |RNA-Dependent RNA Polymerase/*immunology[MESH] |Reassortant Viruses/genetics/*immunology[MESH] |Swine[MESH] |Swine Diseases/immunology/*virology[MESH] |Viral Proteins/*immunology[MESH]Avian influenza A virus PB2 promotes interferon type I inducing proper(epmc).pdf DeepDyve Pubget Overpricing