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10.1016/j.diff.2011.11.004 http://scihub22266oqcxt.onion/10.1016/j.diff.2011.11.004 22364880!ä!22364880 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Differentiation 2012 ; 83 (3): 128-37 Nephropedia Template TP {{tp|p=22364880|t=2012. Integration potential of mouse and human bone marrow-derived mesenchymal stem cells |pdf=|usr=}}{{22364880}} gab.com Text Integration potential of mouse and human bone marrow-derived mesenchymal stem cells JO: Differentiation http://www.kidney.de/pget.php?&tw=1&pmid=22364880 #FOAvip Mesenchymal stem cells (MSCs) are a multipotent cell population which has been described to exert renoprotective and regenerative effects in experimental models of kidney injury. Several lines of evidence indicate that MSCs also have the ability to contribute to nephrogenesis, suggesting that the cells can be employed in stem cell-based applications aimed at de novo renal tissue generation. In this study we re-evaluate the capacity of mouse and human bone marrow-derived MSCs to contribute to the development of renal tissue using a novel method of embryonic kidney culture. Although MSCs show expression of some genes involved in renal development, their contribution to nephrogenesis is very limited in comparison to other stem cell types tested. Furthermore, we found that both mouse and human MSCs have a detrimental effect on the ex vivo development of mouse embryonic kidney, this effect being mediated through a paracrine action. Stimulation with conditioned medium from a mouse renal progenitor population increases the ability of mouse MSCs to integrate into developing renal tissue and prevents the negative effects on kidney development, but does not appear to enhance their ability to undergo nephrogenesis. Twit Text FOAVip Integration potential of mouse and human bone marrow-derived mesenchymal stem cells ????Differentiation http://www.kidney.de/pget.php?&tw=1&pmid=22364880 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22364880 #FOAvip English Wikipedia <ref>{{Cite pmid|22364880}}</ref> Integration potential of mouse and human bone marrow-derived mesenchymal stem cells #MMPMID22364880 Kuzma-Kuzniarska M; Rak-Raszewska A; Kenny S; Edgar D; Wilm B; Fuente Mora C; Davies JA; Murray P Differentiation 2012[Mar]; 83 (3): 128-37 PMID22364880show ga Mesenchymal stem cells (MSCs) are a multipotent cell population which has been described to exert renoprotective and regenerative effects in experimental models of kidney injury. Several lines of evidence indicate that MSCs also have the ability to contribute to nephrogenesis, suggesting that the cells can be employed in stem cell-based applications aimed at de novo renal tissue generation. In this study we re-evaluate the capacity of mouse and human bone marrow-derived MSCs to contribute to the development of renal tissue using a novel method of embryonic kidney culture. Although MSCs show expression of some genes involved in renal development, their contribution to nephrogenesis is very limited in comparison to other stem cell types tested. Furthermore, we found that both mouse and human MSCs have a detrimental effect on the ex vivo development of mouse embryonic kidney, this effect being mediated through a paracrine action. Stimulation with conditioned medium from a mouse renal progenitor population increases the ability of mouse MSCs to integrate into developing renal tissue and prevents the negative effects on kidney development, but does not appear to enhance their ability to undergo nephrogenesis. |*Cell Differentiation[MESH] |*Embryonic Development[MESH] |Animals[MESH] |Bone Marrow Cells/cytology[MESH] |Cells, Cultured[MESH] |Culture Media, Conditioned[MESH] |Gene Expression Regulation, Developmental[MESH] |Humans[MESH] |Kidney/cytology/*growth & development[MESH] |Mesenchymal Stem Cells/cytology/*metabolism[MESH] |Mice[MESH]Integration potential of mouse and human bone marrow-derived mesenchym(epmc).pdf DeepDyve Pubget Overpricing