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Overexpression of HIF-1alpha transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats #MMPMID22349312
Zhu Q; Wang Z; Xia M; Li PL; Zhang F; Li N
Biochim Biophys Acta 2012[Jun]; 1822 (6): 936-41 PMID22349312show ga
Hypoxia inducible factor (HIF)-1alpha-mediated gene activation in the renal medulla in response to high salt intake plays an important role in the control of salt sensitivity of blood pressure. High salt-induced activation of HIF-1alpha in the renal medulla is blunted in Dahl S rats. The present study determined whether the impairment of the renal medullary HIF-1alpha pathway was responsible for salt sensitive hypertension in Dahl S rats. Renal medullary HIF-1alpha levels were induced by either transfection of HIF-1alpha expression plasmid or chronic infusion of CoCl(2) into the renal medulla, which was accompanied by increased expressions of anti-hypertensive genes, cyclooxygenase-2 and heme oxygenase-1. Overexpression of HIF-1alpha transgenes in the renal medulla enhanced the pressure natriuresis, promoted the sodium excretion and reduced sodium retention after salt overload. As a result, hypertension induced by 2-week high salt was significantly attenuated in rats treated with HIF-1alpha plasmid or CoCl(2). These results suggest that an abnormal HIF-1alpha in the renal medulla may represent a novel mechanism mediating salt-sensitive hypertension in Dahl S rats and that induction of HIF-1alpha levels in the renal medulla could be a therapeutic approach for the treatment of salt-sensitive hypertension.
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Biochim+Biophys+Acta 2012 ; 1822 (6): 936-41
