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10.1016/j.bbadis.2012.02.002 http://scihub22266oqcxt.onion/10.1016/j.bbadis.2012.02.002 22349312!3402054!22349312     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochim+Biophys+Acta 2012 ; 1822 (6): 936-41 Nephropedia Template TP {{tp|p=22349312|t=2012. Overexpression of HIF-1alpha transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats |pdf=|usr=}}{{22349312}} gab.com Text Overexpression of HIF-1alpha transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=22349312 #FOAvip Hypoxia inducible factor (HIF)-1alpha-mediated gene activation in the renal medulla in response to high salt intake plays an important role in the control of salt sensitivity of blood pressure. High salt-induced activation of HIF-1alpha in the renal medulla is blunted in Dahl S rats. The present study determined whether the impairment of the renal medullary HIF-1alpha pathway was responsible for salt sensitive hypertension in Dahl S rats. Renal medullary HIF-1alpha levels were induced by either transfection of HIF-1alpha expression plasmid or chronic infusion of CoCl(2) into the renal medulla, which was accompanied by increased expressions of anti-hypertensive genes, cyclooxygenase-2 and heme oxygenase-1. Overexpression of HIF-1alpha transgenes in the renal medulla enhanced the pressure natriuresis, promoted the sodium excretion and reduced sodium retention after salt overload. As a result, hypertension induced by 2-week high salt was significantly attenuated in rats treated with HIF-1alpha plasmid or CoCl(2). These results suggest that an abnormal HIF-1alpha in the renal medulla may represent a novel mechanism mediating salt-sensitive hypertension in Dahl S rats and that induction of HIF-1alpha levels in the renal medulla could be a therapeutic approach for the treatment of salt-sensitive hypertension. Twit Text FOAVip Overexpression of HIF-1alpha transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=22349312 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22349312 #FOAvip English Wikipedia <ref>{{Cite pmid|22349312}}</ref> Overexpression of HIF-1alpha transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats #MMPMID22349312 Zhu Q; Wang Z; Xia M; Li PL; Zhang F; Li N Biochim Biophys Acta 2012[Jun]; 1822 (6): 936-41 PMID22349312show ga Hypoxia inducible factor (HIF)-1alpha-mediated gene activation in the renal medulla in response to high salt intake plays an important role in the control of salt sensitivity of blood pressure. High salt-induced activation of HIF-1alpha in the renal medulla is blunted in Dahl S rats. The present study determined whether the impairment of the renal medullary HIF-1alpha pathway was responsible for salt sensitive hypertension in Dahl S rats. Renal medullary HIF-1alpha levels were induced by either transfection of HIF-1alpha expression plasmid or chronic infusion of CoCl(2) into the renal medulla, which was accompanied by increased expressions of anti-hypertensive genes, cyclooxygenase-2 and heme oxygenase-1. Overexpression of HIF-1alpha transgenes in the renal medulla enhanced the pressure natriuresis, promoted the sodium excretion and reduced sodium retention after salt overload. As a result, hypertension induced by 2-week high salt was significantly attenuated in rats treated with HIF-1alpha plasmid or CoCl(2). These results suggest that an abnormal HIF-1alpha in the renal medulla may represent a novel mechanism mediating salt-sensitive hypertension in Dahl S rats and that induction of HIF-1alpha levels in the renal medulla could be a therapeutic approach for the treatment of salt-sensitive hypertension. |Animals[MESH] |Blood Pressure[MESH] |Cobalt/pharmacology/urine[MESH] |Cyclooxygenase 2/metabolism[MESH] |Heme Oxygenase-1/metabolism[MESH] |Hypertension/genetics/*metabolism[MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/*genetics/*metabolism[MESH] |Kidney Medulla/*metabolism/pathology[MESH] |Male[MESH] |Natriuresis[MESH] |Rats[MESH] |Rats, Inbred Dahl[MESH]Overexpression of HIF-1alpha transgene in the renal medulla attenuated(epmc).pdf DeepDyve Pubget Overpricing