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10.1016/0304-3940(90)90454-h http://scihub22266oqcxt.onion/10.1016/0304-3940(90)90454-h 2234498!ä!2234498 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neurosci+Lett 1990 ; 115 (2-3): 195-200 Nephropedia Template TP {{tp|p=2234498|t=1990. Potassium channel activators abolish excitotoxicity in cultured hippocampal pyramidal neurons |pdf=|usr=}}{{2234498}} gab.com Text Potassium channel activators abolish excitotoxicity in cultured hippocampal pyramidal neurons JO: Neurosci Lett http://www.kidney.de/pget.php?&tw=1&pmid=2234498 #FOAvip When hippocampal pyramidal neurons are grown in culture they develop excitatory synaptic contacts. If these cultures are perfused with Mg2(+)-free, glycine supplemented medium the neurons exhibit fluctuations in [Ca2+]i and associated cell death ('excitotoxicity'). These phenomena involve the activation of NMDA receptors. When cultures are treated with the K(+)-channel activators cromakalim and diazoxide both the [Ca2+]i fluctuations and the neuronal death are abolished. These effects are reversed by the sulfonylurea glyburide. It thus appears that K(+)-channel activators may be a novel therapeutic intervention in epilepsy and associated disorders. Twit Text FOAVip Potassium channel activators abolish excitotoxicity in cultured hippocampal pyramidal neurons ????Neurosci Lett http://www.kidney.de/pget.php?&tw=1&pmid=2234498 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=2234498 #FOAvip English Wikipedia <ref>{{Cite pmid|2234498}}</ref> Potassium channel activators abolish excitotoxicity in cultured hippocampal pyramidal neurons #MMPMID2234498 Abele AE; Miller RJ Neurosci Lett 1990[Jul]; 115 (2-3): 195-200 PMID2234498show ga When hippocampal pyramidal neurons are grown in culture they develop excitatory synaptic contacts. If these cultures are perfused with Mg2(+)-free, glycine supplemented medium the neurons exhibit fluctuations in [Ca2+]i and associated cell death ('excitotoxicity'). These phenomena involve the activation of NMDA receptors. When cultures are treated with the K(+)-channel activators cromakalim and diazoxide both the [Ca2+]i fluctuations and the neuronal death are abolished. These effects are reversed by the sulfonylurea glyburide. It thus appears that K(+)-channel activators may be a novel therapeutic intervention in epilepsy and associated disorders. |Action Potentials/drug effects[MESH] |Animals[MESH] |Benzopyrans/*pharmacology[MESH] |Cell Survival/drug effects[MESH] |Cells, Cultured[MESH] |Cromakalim[MESH] |Diazoxide/*pharmacology[MESH] |Hippocampus/drug effects/*physiology[MESH] |Potassium Channels/drug effects/*physiology[MESH] |Pyrroles/*pharmacology[MESH]Potassium channel activators abolish excitotoxicity in cultured hippoc(epmc).pdf DeepDyve Pubget Overpricing