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10.1152/ajprenal.00646.2011 http://scihub22266oqcxt.onion/10.1152/ajprenal.00646.2011 22338089!3362169!22338089     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Renal+Physiol 2012 ; 302 (9): F1069-81 Nephropedia Template TP {{tp|p=22338089|t=2012. Basolateral membrane K+ channels in renal epithelial cells |pdf=|usr=}}{{22338089}} gab.com Text Basolateral membrane K+ channels in renal epithelial cells JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=22338089 #FOAvip The major function of epithelial tissues is to maintain proper ion, solute, and water homeostasis. The tubule of the renal nephron has an amazingly simple structure, lined by epithelial cells, yet the segments (i.e., proximal tubule vs. collecting duct) of the nephron have unique transport functions. The functional differences are because epithelial cells are polarized and thus possess different patterns (distributions) of membrane transport proteins in the apical and basolateral membranes of the cell. K(+) channels play critical roles in normal physiology. Over 90 different genes for K(+) channels have been identified in the human genome. Epithelial K(+) channels can be located within either or both the apical and basolateral membranes of the cell. One of the primary functions of basolateral K(+) channels is to recycle K(+) across the basolateral membrane for proper function of the Na(+)-K(+)-ATPase, among other functions. Mutations of these channels can cause significant disease. The focus of this review is to provide an overview of the basolateral K(+) channels of the nephron, providing potential physiological functions and pathophysiology of these channels, where appropriate. We have taken a "K(+) channel gene family" approach in presenting the representative basolateral K(+) channels of the nephron. The basolateral K(+) channels of the renal epithelia are represented by members of the KCNK, KCNJ, KCNQ, KCNE, and SLO gene families. Twit Text FOAVip Basolateral membrane K+ channels in renal epithelial cells ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=22338089 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22338089 #FOAvip English Wikipedia <ref>{{Cite pmid|22338089}}</ref> Basolateral membrane K+ channels in renal epithelial cells #MMPMID22338089 Hamilton KL; Devor DC Am J Physiol Renal Physiol 2012[May]; 302 (9): F1069-81 PMID22338089show ga The major function of epithelial tissues is to maintain proper ion, solute, and water homeostasis. The tubule of the renal nephron has an amazingly simple structure, lined by epithelial cells, yet the segments (i.e., proximal tubule vs. collecting duct) of the nephron have unique transport functions. The functional differences are because epithelial cells are polarized and thus possess different patterns (distributions) of membrane transport proteins in the apical and basolateral membranes of the cell. K(+) channels play critical roles in normal physiology. Over 90 different genes for K(+) channels have been identified in the human genome. Epithelial K(+) channels can be located within either or both the apical and basolateral membranes of the cell. One of the primary functions of basolateral K(+) channels is to recycle K(+) across the basolateral membrane for proper function of the Na(+)-K(+)-ATPase, among other functions. Mutations of these channels can cause significant disease. The focus of this review is to provide an overview of the basolateral K(+) channels of the nephron, providing potential physiological functions and pathophysiology of these channels, where appropriate. We have taken a "K(+) channel gene family" approach in presenting the representative basolateral K(+) channels of the nephron. The basolateral K(+) channels of the renal epithelia are represented by members of the KCNK, KCNJ, KCNQ, KCNE, and SLO gene families. |Cell Membrane/*physiology[MESH] |Epithelial Cells/*physiology[MESH] |Homeostasis/physiology[MESH] |Humans[MESH] |Kidney/cytology/*physiology[MESH] |Potassium Channels/*genetics/*physiology[MESH] |Potassium/metabolism[MESH]Basolateral membrane K+ channels in renal epithelial cells (epmc).pdf DeepDyve Pubget Overpricing