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10.3109/0886022X.2012.656561

http://scihub22266oqcxt.onion/10.3109/0886022X.2012.656561
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22299661!4861151!22299661
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suck abstract from ncbi


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pmid22299661      Ren+Fail 2012 ; 34 (4): 408-12
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  • The effect of different dialysate magnesium concentrations on QTc dispersion in hemodialysis patients #MMPMID22299661
  • Afshinnia F; Doshi H; Rao PS
  • Ren Fail 2012[]; 34 (4): 408-12 PMID22299661show ga
  • BACKGROUND: Electrolyte changes during dialysis affect corrected QT (QTc) and QTc dispersion (QTcd), a surrogate marker of arrhythmogenicity. The impact of magnesium on QTcd is not clear. METHODS: Twenty-two stable patients on maintenance hemodialysis were enrolled in this study. Each underwent two consecutive hemodialysis sessions at least 2 days apart, the first against normal magnesium dialysate (with magnesium at 1.8 mg/dL) followed by a low magnesium dialysate (with magnesium at 0.6 mg/dL). Pre- and post-dialysis weights, blood pressure, electrolytes, and 12-lead surface EKG were recorded. The QT interval and the QTcd were calculated before and after dialysis in both sessions. RESULTS: Of 22 patients, 16 were female. The mean age +/- SD was 53.7 +/- 18.0 years. The mean change of QTcd (pre- vs. post-dialysis) was 9.5 ms (p = 0.120) and 9.3 ms (p = 0.145) in low and normal magnesium groups, respectively. Using univariate analysis, there was a statistically significant decrease in the mean blood pressure, weight, potassium, magnesium, and QTc interval post-dialysis (compared to pre-dialysis) in both groups (p
  • |*Renal Dialysis[MESH]
  • |Arrhythmias, Cardiac/etiology/metabolism/*physiopathology[MESH]
  • |Cross-Over Studies[MESH]
  • |Dialysis Solutions/*chemistry[MESH]
  • |Electrocardiography/*drug effects[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Kidney Failure, Chronic/complications/metabolism/*therapy[MESH]
  • |Magnesium/*analysis/pharmacokinetics[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]


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