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10.1016/j.tiv.2012.01.016 http://scihub22266oqcxt.onion/10.1016/j.tiv.2012.01.016 22269387!ä!22269387 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Toxicol+In+Vitro 2012 ; 26 (3): 455-61 Nephropedia Template TP {{tp|p=22269387|t=2012. Protective effects of paeoniflorin against cobalt chloride-induced apoptosis of endothelial cells via HIF-1alpha pathway |pdf=|usr=}}{{22269387}} gab.com Text Protective effects of paeoniflorin against cobalt chloride-induced apoptosis of endothelial cells via HIF-1alpha pathway JO: Toxicol In Vitro http://www.kidney.de/pget.php?&tw=1&pmid=22269387 #FOAvip Accumulating evidence has suggested the importance of hypoxia in the initiation and development of atherosclerotic lesion, and hypoxia has a profound impact on endothelial cell properties during cardiovascular disease processes. Paeoniflorin, isolated from the root of Paeonia lactiflora pall, can protect endothelial cells from hypoxic damage in a variety of ways, such as by enhancing the production of nitric oxide (NO) and decreasing the expressions of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). This study evaluated the protective effects of paeoniflorin against cobalt chloride (CoCl2, a hypoxia-mimicking agent)-induced apoptosis of endothelial cells (CRL-1730) and the underlying mechanisms in vitro. Endothelial cells were exposed to CoCl2 with or without pre-treatment with different concentrations of paeoniflorin. After treated with 0.6mM CoCl2 for 24 h, endothelial cells showed significant decrease in cell viability and increased apoptosis rate, which could be reversed by pre-treatment with paeoniflorin. Similarly, pre-treatment with paeoniflorin could prevent CoCl2-induced hypoxia-induced factor-1alpha (HIF-1alpha) accumulation and down-regulate the expressions of p53 and Bcl-2/adenovirus E1B 19kDa interacting protein 3 (BNIP3). These findings indicate that paeoniflorin had effective protection against hypoxia-induced apoptosis of endothelial cells and that HIF-1alpha, p53 and BNIP3 might be involved in this process. Twit Text FOAVip Protective effects of paeoniflorin against cobalt chloride-induced apoptosis of endothelial cells via HIF-1alpha pathway ????Toxicol In Vitro http://www.kidney.de/pget.php?&tw=1&pmid=22269387 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22269387 #FOAvip English Wikipedia <ref>{{Cite pmid|22269387}}</ref> Protective effects of paeoniflorin against cobalt chloride-induced apoptosis of endothelial cells via HIF-1alpha pathway #MMPMID22269387 Ji Q; Yang L; Zhou J; Lin R; Zhang J; Lin Q; Wang W; Zhang K Toxicol In Vitro 2012[Apr]; 26 (3): 455-61 PMID22269387show ga Accumulating evidence has suggested the importance of hypoxia in the initiation and development of atherosclerotic lesion, and hypoxia has a profound impact on endothelial cell properties during cardiovascular disease processes. Paeoniflorin, isolated from the root of Paeonia lactiflora pall, can protect endothelial cells from hypoxic damage in a variety of ways, such as by enhancing the production of nitric oxide (NO) and decreasing the expressions of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). This study evaluated the protective effects of paeoniflorin against cobalt chloride (CoCl2, a hypoxia-mimicking agent)-induced apoptosis of endothelial cells (CRL-1730) and the underlying mechanisms in vitro. Endothelial cells were exposed to CoCl2 with or without pre-treatment with different concentrations of paeoniflorin. After treated with 0.6mM CoCl2 for 24 h, endothelial cells showed significant decrease in cell viability and increased apoptosis rate, which could be reversed by pre-treatment with paeoniflorin. Similarly, pre-treatment with paeoniflorin could prevent CoCl2-induced hypoxia-induced factor-1alpha (HIF-1alpha) accumulation and down-regulate the expressions of p53 and Bcl-2/adenovirus E1B 19kDa interacting protein 3 (BNIP3). These findings indicate that paeoniflorin had effective protection against hypoxia-induced apoptosis of endothelial cells and that HIF-1alpha, p53 and BNIP3 might be involved in this process. |Apoptosis/*drug effects[MESH] |Benzoates/administration & dosage/isolation & purification/*pharmacology[MESH] |Bridged-Ring Compounds/administration & dosage/isolation & purification/*pharmacology[MESH] |Cell Hypoxia/drug effects[MESH] |Cell Line[MESH] |Cell Survival/drug effects[MESH] |Cobalt/*toxicity[MESH] |Dose-Response Relationship, Drug[MESH] |Gene Expression Regulation/drug effects[MESH] |Glucosides/administration & dosage/isolation & purification/*pharmacology[MESH] |Human Umbilical Vein Endothelial Cells/*drug effects/metabolism[MESH] |Humans[MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/genetics/metabolism[MESH] |Membrane Proteins/genetics/metabolism[MESH] |Monoterpenes[MESH] |Nitric Oxide/metabolism[MESH] |Paeonia/chemistry[MESH] |Plant Roots[MESH] |Proto-Oncogene Proteins/genetics/metabolism[MESH]Protective effects of paeoniflorin against cobalt chloride-induced apo(epmc).pdf DeepDyve Pubget Overpricing