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10.1016/j.bbamem.2011.12.024 http://scihub22266oqcxt.onion/10.1016/j.bbamem.2011.12.024 22230350!ä!22230350 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochim+Biophys+Acta 2012 ; 1818 (5): 1135-41 Nephropedia Template TP {{tp|p=22230350|t=2012. A calcium-permeable non-selective cation channel in the thick ascending limb apical membrane of the mouse kidney |pdf=|usr=}}{{22230350}} gab.com Text A calcium-permeable non-selective cation channel in the thick ascending limb apical membrane of the mouse kidney JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=22230350 #FOAvip Non-selective cation channels have been described in the basolateral membrane of the renal tubule, but little is known about functional channels on the apical side. Apical membranes of microdissected fragments of mouse cortical thick ascending limbs were searched for ion channels using the cell-free configuration of the patch-clamp technique. A cation channel with a linear current-voltage relationship (19pS) that was permeable both to monovalent cations [P(NH4)(1.7)>P(Na) (1.0)=P(K) (1.0)] and to Ca(2+) (P(Ca)/P(Na) approximately 0.3) was detected. Unlike the basolateral TRPM4 Ca(2+)-impermeable non-selective cation channel, this non-selective cation channel was insensitive to internal Ca(2+), pH and ATP. The channel was already active after patch excision, and its activity increased after reduced pressure was applied via the pipette. External gadolinium (10(-5)M) decreased the channel-open probability by 70% in outside-out patches, whereas external amiloride (10(-4)M) had no effect. Internal flufenamic acid (10(-4)M) inhibited the channel in inside-out patches. Its properties suggest that the current might be supported by the TRPM7 protein that is expressed in the loop of Henle. The conduction properties of the channel suggest that it could be involved in Ca(2+) signaling. Twit Text FOAVip A calcium-permeable non-selective cation channel in the thick ascending limb apical membrane of the mouse kidney ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=22230350 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22230350 #FOAvip English Wikipedia <ref>{{Cite pmid|22230350}}</ref> A calcium-permeable non-selective cation channel in the thick ascending limb apical membrane of the mouse kidney #MMPMID22230350 Guinamard R; Paulais M; Lourdel S; Teulon J Biochim Biophys Acta 2012[May]; 1818 (5): 1135-41 PMID22230350show ga Non-selective cation channels have been described in the basolateral membrane of the renal tubule, but little is known about functional channels on the apical side. Apical membranes of microdissected fragments of mouse cortical thick ascending limbs were searched for ion channels using the cell-free configuration of the patch-clamp technique. A cation channel with a linear current-voltage relationship (19pS) that was permeable both to monovalent cations [P(NH4)(1.7)>P(Na) (1.0)=P(K) (1.0)] and to Ca(2+) (P(Ca)/P(Na) approximately 0.3) was detected. Unlike the basolateral TRPM4 Ca(2+)-impermeable non-selective cation channel, this non-selective cation channel was insensitive to internal Ca(2+), pH and ATP. The channel was already active after patch excision, and its activity increased after reduced pressure was applied via the pipette. External gadolinium (10(-5)M) decreased the channel-open probability by 70% in outside-out patches, whereas external amiloride (10(-4)M) had no effect. Internal flufenamic acid (10(-4)M) inhibited the channel in inside-out patches. Its properties suggest that the current might be supported by the TRPM7 protein that is expressed in the loop of Henle. The conduction properties of the channel suggest that it could be involved in Ca(2+) signaling. |Adenosine Triphosphate/metabolism[MESH] |Animals[MESH] |Anti-Inflammatory Agents/pharmacology[MESH] |Calcium Signaling/drug effects/*physiology[MESH] |Calcium/*metabolism[MESH] |Flufenamic Acid/pharmacology[MESH] |Hydrogen-Ion Concentration[MESH] |Ion Channel Gating/drug effects/*physiology[MESH] |Ion Transport/drug effects/physiology[MESH] |Loop of Henle/*metabolism[MESH] |Male[MESH] |Mice[MESH]A calcium-permeable non-selective cation channel in the thick ascendin(epmc).pdf DeepDyve Pubget Overpricing