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10.3109/00952990.2011.644002 http://scihub22266oqcxt.onion/10.3109/00952990.2011.644002 22221171/?report=reader!5377928!22221171     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Drug+Alcohol+Abuse 2012 ; 38 (2): 181-6 Nephropedia Template TP {{tp|p=22221171|t=2012. The efficacy of mirtazapine in the treatment of cocaine dependence with comorbid depression |pdf=|usr=}}{{22221171}} gab.com Text The efficacy of mirtazapine in the treatment of cocaine dependence with comorbid depression JO: Am J Drug Alcohol Abuse http://www.kidney.de/pget.php?&tw=1&pmid=22221171 #FOAvip BACKGROUND: Prior findings concerning the use of mirtazapine in the treatment of a variety of substance use disorders and its antagonistic actions at the serotonin 5-HT(2A) receptor suggest that this drug may have efficacy in the treatment of cocaine dependence in the presence of a depressive disorder. METHODS: Depressed cocaine-dependent subjects received either mirtazapine (target dose 45 mg daily) or placebo for 12 weeks. Urine concentrations of benzoylecgonine and self-report were used to assess cocaine consumption. Depression and sleep quality were evaluated using the Hamilton Depression Rating Scale (HAM-D) and the Pittsburgh Sleep Quality Index, respectively. RESULTS: Cocaine consumption during the treatment period did not differ significantly between the mirtazapine (n = 11) and placebo (n = 13) groups in this study. In week 4 sleep latency was significantly lower in the active medication than in the placebo group. Positive effects of mirtazapine treatment on early insomnia were suggested by an item analysis of the HAM-D. CONCLUSIONS AND SCIENTIFIC SIGNIFICANCE: The results of this study suggest that mirtazapine is superior to placebo in improving sleep in patients with comorbid depression and cocaine dependence, but is not more effective than placebo in reducing cocaine use. Twit Text FOAVip The efficacy of mirtazapine in the treatment of cocaine dependence with comorbid depression ????Am J Drug Alcohol Abuse http://www.kidney.de/pget.php?&tw=1&pmid=22221171 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22221171 #FOAvip English Wikipedia <ref>{{Cite pmid|22221171}}</ref> The efficacy of mirtazapine in the treatment of cocaine dependence with comorbid depression #MMPMID22221171 Afshar M; Knapp CM; Sarid-Segal O; Devine E; Colaneri LS; Tozier L; Waters ME; Putnam MA; Ciraulo DA Am J Drug Alcohol Abuse 2012[Mar]; 38 (2): 181-6 PMID22221171show ga BACKGROUND: Prior findings concerning the use of mirtazapine in the treatment of a variety of substance use disorders and its antagonistic actions at the serotonin 5-HT(2A) receptor suggest that this drug may have efficacy in the treatment of cocaine dependence in the presence of a depressive disorder. METHODS: Depressed cocaine-dependent subjects received either mirtazapine (target dose 45 mg daily) or placebo for 12 weeks. Urine concentrations of benzoylecgonine and self-report were used to assess cocaine consumption. Depression and sleep quality were evaluated using the Hamilton Depression Rating Scale (HAM-D) and the Pittsburgh Sleep Quality Index, respectively. RESULTS: Cocaine consumption during the treatment period did not differ significantly between the mirtazapine (n = 11) and placebo (n = 13) groups in this study. In week 4 sleep latency was significantly lower in the active medication than in the placebo group. Positive effects of mirtazapine treatment on early insomnia were suggested by an item analysis of the HAM-D. CONCLUSIONS AND SCIENTIFIC SIGNIFICANCE: The results of this study suggest that mirtazapine is superior to placebo in improving sleep in patients with comorbid depression and cocaine dependence, but is not more effective than placebo in reducing cocaine use. |Adult[MESH] |Antidepressive Agents, Tricyclic/*therapeutic use[MESH] |Cocaine-Related Disorders/complications/*drug therapy[MESH] |Cocaine/*administration & dosage[MESH] |Depressive Disorder/complications/*drug therapy[MESH] |Double-Blind Method[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Mianserin/*analogs & derivatives/therapeutic use[MESH] |Middle Aged[MESH] |Mirtazapine[MESH] |Self Report[MESH]The efficacy of mirtazapine in the treatment of cocaine dependence wit(epmc).pdf DeepDyve Pubget Overpricing