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10.1073/pnas.1120033109 http://scihub22266oqcxt.onion/10.1073/pnas.1120033109 22203997!3277139!22203997     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22203997&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Proc+Natl+Acad+Sci+U+S+A 2012 ; 109 (5): E225-33 Nephropedia Template TP {{tp|p=22203997|t=2012. The channel kinase, TRPM7, is required for early embryonic development |pdf=|usr=}}{{22203997}} gab.com Text The channel kinase, TRPM7, is required for early embryonic development JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=22203997 #FOAvip Global disruption of transient receptor potential-melastatin-like 7 (Trpm7) in mice results in embryonic lethality before embryonic day 7. Using tamoxifen-inducible disruption of Trpm7 and multiple Cre recombinase lines, we show that Trpm7 deletion before and during organogenesis results in severe tissue-specific developmental defects. We find that Trpm7 is essential for kidney development from metanephric mesenchyme but not ureteric bud. Disruption of neural crest Trpm7 at early stages results in loss of pigment cells and dorsal root ganglion neurons. In contrast, late disruption of brain-specific Trpm7 after embryonic day 10.5 does not alter normal brain development. We developed induced pluripotent stem cells and neural stem (NS) cells in which Trpm7 disruption could be induced. Trpm7(-/-) NS cells retained the capacities of self-renewal and differentiation into neurons and astrocytes. During in vitro differentiation of induced pluripotent stem cells to NS cells, Trpm7 disruption prevents the formation of the NS cell monolayer. The in vivo and in vitro results demonstrate a temporal requirement for the Trpm7 channel kinase during embryogenesis. Twit Text FOAVip The channel kinase, TRPM7, is required for early embryonic development ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=22203997 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22203997 #FOAvip English Wikipedia <ref>{{Cite pmid|22203997}}</ref> The channel kinase, TRPM7, is required for early embryonic development #MMPMID22203997 Jin J; Wu LJ; Jun J; Cheng X; Xu H; Andrews NC; Clapham DE Proc Natl Acad Sci U S A 2012[Jan]; 109 (5): E225-33 PMID22203997show ga Global disruption of transient receptor potential-melastatin-like 7 (Trpm7) in mice results in embryonic lethality before embryonic day 7. Using tamoxifen-inducible disruption of Trpm7 and multiple Cre recombinase lines, we show that Trpm7 deletion before and during organogenesis results in severe tissue-specific developmental defects. We find that Trpm7 is essential for kidney development from metanephric mesenchyme but not ureteric bud. Disruption of neural crest Trpm7 at early stages results in loss of pigment cells and dorsal root ganglion neurons. In contrast, late disruption of brain-specific Trpm7 after embryonic day 10.5 does not alter normal brain development. We developed induced pluripotent stem cells and neural stem (NS) cells in which Trpm7 disruption could be induced. Trpm7(-/-) NS cells retained the capacities of self-renewal and differentiation into neurons and astrocytes. During in vitro differentiation of induced pluripotent stem cells to NS cells, Trpm7 disruption prevents the formation of the NS cell monolayer. The in vivo and in vitro results demonstrate a temporal requirement for the Trpm7 channel kinase during embryogenesis. |Animals[MESH] |Cell Differentiation[MESH] |Embryonic Development/*physiology[MESH] |Female[MESH] |Intermediate Filament Proteins/physiology[MESH] |Male[MESH] |Mice[MESH] |Mice, Transgenic[MESH] |Nerve Tissue Proteins/physiology[MESH] |Nestin[MESH] |Pluripotent Stem Cells/cytology[MESH]The channel kinase, TRPM7, is required for early embryonic development(epmc).pdf DeepDyve Pubget Overpricing