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10.2741/s320 http://scihub22266oqcxt.onion/10.2741/s320 22202111!3841983!22202111     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Biosci+(Schol+Ed) 2012 ; 4 (3): 1088-98 Nephropedia Template TP {{tp|p=22202111|t=2012. Sensory functions of motile cilia and implication for bronchiectasis |pdf=|usr=}}{{22202111}} gab.com Text Sensory functions of motile cilia and implication for bronchiectasis JO: Front Biosci (Schol Ed) http://www.kidney.de/pget.php?&tw=1&pmid=22202111 #FOAvip Cilia are specialized organelles that extend from the cell surface into the local environment. Cilia of the airway epithelia are motile to provide mucociliary clearance. On other cells, solitary cilia are specialized to detect chemical or mechanosensory signals. Sensory proteins in motile cilia have recently been identified that detect fluid flow, bitter taste and sex hormones. The relationship of these sensory functions in motile cilia to disease is now being revealed. An example are the polycystin-1 and polycystin-2 proteins that function as a flow sensor in kidney cilia and are mutated in autosomal dominant polycystic kidney disease (ADPKD). These polycystins are also expressed in motile cilia, potentially operating as sensors in the lung. Computed tomography studies from patients with ADPKD reveal evidence of bronchiectasis, suggesting polycystins are important in lung function. The motile cilia expression of this protein complex, as well as sensory channel TRPV4, bitter taste and sex hormones receptors, indicate that the cilia is wired to interpret environmental cues. Defective signaling of sensory proteins may result in a ciliopathy that includes lung disease. Twit Text FOAVip Sensory functions of motile cilia and implication for bronchiectasis ????Front Biosci (Schol Ed) http://www.kidney.de/pget.php?&tw=1&pmid=22202111 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22202111 #FOAvip English Wikipedia <ref>{{Cite pmid|22202111}}</ref> Sensory functions of motile cilia and implication for bronchiectasis #MMPMID22202111 Jain R; Javidan-Nejad C; Alexander-Brett J; Horani A; Cabellon MC; Walter MJ; Brody SL Front Biosci (Schol Ed) 2012[Jan]; 4 (3): 1088-98 PMID22202111show ga Cilia are specialized organelles that extend from the cell surface into the local environment. Cilia of the airway epithelia are motile to provide mucociliary clearance. On other cells, solitary cilia are specialized to detect chemical or mechanosensory signals. Sensory proteins in motile cilia have recently been identified that detect fluid flow, bitter taste and sex hormones. The relationship of these sensory functions in motile cilia to disease is now being revealed. An example are the polycystin-1 and polycystin-2 proteins that function as a flow sensor in kidney cilia and are mutated in autosomal dominant polycystic kidney disease (ADPKD). These polycystins are also expressed in motile cilia, potentially operating as sensors in the lung. Computed tomography studies from patients with ADPKD reveal evidence of bronchiectasis, suggesting polycystins are important in lung function. The motile cilia expression of this protein complex, as well as sensory channel TRPV4, bitter taste and sex hormones receptors, indicate that the cilia is wired to interpret environmental cues. Defective signaling of sensory proteins may result in a ciliopathy that includes lung disease. |Animals[MESH] |Bronchiectasis/*metabolism/*pathology[MESH] |Cilia/*metabolism/*pathology[MESH] |Humans[MESH] |Kidney/metabolism/pathology[MESH] |Lung/metabolism/pathology[MESH] |Polycystic Kidney, Autosomal Dominant/metabolism/pathology[MESH] |Sensation[MESH] |Sensory Receptor Cells/*metabolism[MESH] |Signal Transduction[MESH]Sensory functions of motile cilia and implication for bronchiectasis (epmc).pdf DeepDyve Pubget Overpricing