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10.1111/boc.201100105

http://scihub22266oqcxt.onion/10.1111/boc.201100105
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22188262!3625690!22188262
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suck abstract from ncbi


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pmid22188262      Biol+Cell 2012 ; 104 (3): 121-38
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  • Regulation of the nucleocytoplasmic trafficking of viral and cellular proteins by ubiquitin and small ubiquitin-related modifiers #MMPMID22188262
  • Wang YE; Pernet O; Lee B
  • Biol Cell 2012[Mar]; 104 (3): 121-38 PMID22188262show ga
  • Nucleocytoplasmic trafficking of many cellular proteins is regulated by nuclear import/export signals as well as post-translational modifications such as covalent conjugation of ubiquitin and small ubiquitin-related modifiers (SUMOs). Ubiquitination and SUMOylation are rapid and reversible ways to modulate the intracellular localisation and function of substrate proteins. These pathways have been co-opted by some viruses, which depend on the host cell machinery to transport their proteins in and out of the nucleus. In this review, we will summarise our current knowledge on the ubiquitin/SUMO-regulated nuclear/subnuclear trafficking of cellular proteins and describe examples of viral exploitation of these pathways.
  • |*Protein Transport[MESH]
  • |Animals[MESH]
  • |Cell Nucleus/*metabolism[MESH]
  • |Cytoplasm/metabolism[MESH]
  • |Humans[MESH]
  • |Proteins/*metabolism[MESH]
  • |Signal Transduction[MESH]
  • |Small Ubiquitin-Related Modifier Proteins/*metabolism[MESH]
  • |Ubiquitin/*metabolism[MESH]


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