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10.1111/j.1360-0443.2011.03766.x http://scihub22266oqcxt.onion/10.1111/j.1360-0443.2011.03766.x 22168398/?report=reader!3389790!22168398     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Addiction 2012 ; 107 (6): 1140-7 Nephropedia Template TP {{tp|p=22168398|t=2012. Influence of acute bupropion pre-treatment on the effects of intranasal cocaine |pdf=|usr=}}{{22168398}} gab.com Text Influence of acute bupropion pre-treatment on the effects of intranasal cocaine JO: Addiction http://www.kidney.de/pget.php?&tw=1&pmid=22168398 #FOAvip AIMS: The aim of this experiment was to determine the influence of acute bupropion pre-treatment on subject-rated effects and choice of intranasal cocaine versus money. DESIGN: A randomized, within-subject, placebo-controlled, double-blind experiment. SETTING: An out-patient research unit. PARTICIPANTS: Eight cocaine-using adults. MEASUREMENTS: Subjects completed nine experimental sessions in which they were pre-treated with 0, 100 or 200 mg oral immediate release bupropion. Ninety minutes later they sampled an intranasal cocaine dose [4 (placebo), 15 or 45 mg] and made six choices between that dose and an alternative reinforcer (US$0.25), available on independent, concurrent progressive ratio schedules. Subjects also completed a battery of subject-rated, performance and physiological measures following the sample doses of cocaine. FINDINGS: After 0 mg bupropion, the high dose of cocaine (45 mg) was chosen five of six times on average compared to 2.25 of six choices for placebo cocaine (4 mg) (P < 0.05). Active bupropion reduced choice of 45 mg cocaine to 3.13 (100 mg) or 4.00 (200 mg) out of six drug choices on average. Bupropion also consistently enhanced positive subject-rated effects of cocaine (e.g. good effects; willing to take again) while having no effects of its own. CONCLUSIONS: The atypical antidepressant, bupropion, acutely appears to reduce preference for intranasal cocaine versus a small amount of money but to increase reported positive experiences of the drug. Twit Text FOAVip Influence of acute bupropion pre-treatment on the effects of intranasal cocaine ????Addiction http://www.kidney.de/pget.php?&tw=1&pmid=22168398 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22168398 #FOAvip English Wikipedia <ref>{{Cite pmid|22168398}}</ref> Influence of acute bupropion pre-treatment on the effects of intranasal cocaine #MMPMID22168398 Stoops WW; Lile JA; Glaser PE; Hays LR; Rush CR Addiction 2012[Jun]; 107 (6): 1140-7 PMID22168398show ga AIMS: The aim of this experiment was to determine the influence of acute bupropion pre-treatment on subject-rated effects and choice of intranasal cocaine versus money. DESIGN: A randomized, within-subject, placebo-controlled, double-blind experiment. SETTING: An out-patient research unit. PARTICIPANTS: Eight cocaine-using adults. MEASUREMENTS: Subjects completed nine experimental sessions in which they were pre-treated with 0, 100 or 200 mg oral immediate release bupropion. Ninety minutes later they sampled an intranasal cocaine dose [4 (placebo), 15 or 45 mg] and made six choices between that dose and an alternative reinforcer (US$0.25), available on independent, concurrent progressive ratio schedules. Subjects also completed a battery of subject-rated, performance and physiological measures following the sample doses of cocaine. FINDINGS: After 0 mg bupropion, the high dose of cocaine (45 mg) was chosen five of six times on average compared to 2.25 of six choices for placebo cocaine (4 mg) (P < 0.05). Active bupropion reduced choice of 45 mg cocaine to 3.13 (100 mg) or 4.00 (200 mg) out of six drug choices on average. Bupropion also consistently enhanced positive subject-rated effects of cocaine (e.g. good effects; willing to take again) while having no effects of its own. CONCLUSIONS: The atypical antidepressant, bupropion, acutely appears to reduce preference for intranasal cocaine versus a small amount of money but to increase reported positive experiences of the drug. |Administration, Oral[MESH] |Adult[MESH] |Antidepressive Agents, Second-Generation/administration & dosage/*pharmacology[MESH] |Bupropion/administration & dosage/*pharmacology[MESH] |Choice Behavior/*drug effects[MESH] |Cocaine-Related Disorders/*psychology[MESH] |Cocaine/*administration & dosage[MESH] |Dopamine Uptake Inhibitors/*administration & dosage[MESH] |Dose-Response Relationship, Drug[MESH] |Double-Blind Method[MESH] |Drug Interactions[MESH] |Female[MESH] |Humans[MESH] |Male[MESH]Influence of acute bupropion pre-treatment on the effects of intranasa(epmc).pdf DeepDyve Pubget Overpricing