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10.1016/j.medin.2011.10.005 http://scihub22266oqcxt.onion/10.1016/j.medin.2011.10.005 22154847!ä!22154847 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Med+Intensiva 2012 ; 36 (1): 24-31 Nephropedia Template TP {{tp|p=22154847|t=2012. Lung histopathological findings in fatal pandemic influenza A (H1N1) |pdf=|usr=}}{{22154847}} gab.com Text Lung histopathological findings in fatal pandemic influenza A (H1N1) JO: Med Intensiva http://www.kidney.de/pget.php?&tw=1&pmid=22154847 #FOAvip OBJECTIVE: To describe the lung pathological changes in influenza A (H1N1) viral pneumonia. We studied morphological changes, nitro-oxidative stress and the presence of viral proteins in lung tissue. METHODS AND PATIENTS: Light microscopy was used to examine lung tissue from 6 fatal cases of pandemic influenza A (H1N1) viral pneumonia. Fluorescence for oxidized dihydroethydium, nitrotyrosine, inducible NO synthase (NOS2) and human influenza A nucleoprotein (NP) (for analysis under confocal microscopy) was also studied in lung tissue specimens. RESULTS: Age ranged from 15 to 50 years. Three patients were women, and 5 had preexisting medical conditions. Diffuse alveolar damage (DAD) was present in 5 cases (as evidenced by hyaline membrane formation, alveolo-capillary wall thickening and PMN infiltrates), and interstitial fibrosis in one case. In the fluorescence studies there were signs of oxygen radical generation, increased NOS2 protein and protein nitration in lung tissue samples, regardless of the duration of ICU admission. Viral NP was found in lung tissue samples from three patients. Type I pneumocytes and macrophages harbored viral NP, as evidenced by confocal immunofluorescence microscopy. CONCLUSIONS: Lung tissue from patients with pandemic influenza A (H1N1) viral pneumonia shows histological findings consistent with DAD. Prolonged nitro-oxidative stress is present despite antiviral treatment. Viral proteins may remain in lung tissue for prolonged periods of time, lodged in macrophages and type I pneumocytes. Twit Text FOAVip Lung histopathological findings in fatal pandemic influenza A (H1N1) ????Med Intensiva http://www.kidney.de/pget.php?&tw=1&pmid=22154847 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22154847 #FOAvip English Wikipedia <ref>{{Cite pmid|22154847}}</ref> Lung histopathological findings in fatal pandemic influenza A (H1N1) #MMPMID22154847 Nin N; Sanchez-Rodriguez C; Ver LS; Cardinal P; Ferruelo A; Soto L; Deicas A; Campos N; Rocha O; Ceraso DH; El-Assar M; Ortin J; Fernandez-Segoviano P; Esteban A; Lorente JA Med Intensiva 2012[Jan]; 36 (1): 24-31 PMID22154847show ga OBJECTIVE: To describe the lung pathological changes in influenza A (H1N1) viral pneumonia. We studied morphological changes, nitro-oxidative stress and the presence of viral proteins in lung tissue. METHODS AND PATIENTS: Light microscopy was used to examine lung tissue from 6 fatal cases of pandemic influenza A (H1N1) viral pneumonia. Fluorescence for oxidized dihydroethydium, nitrotyrosine, inducible NO synthase (NOS2) and human influenza A nucleoprotein (NP) (for analysis under confocal microscopy) was also studied in lung tissue specimens. RESULTS: Age ranged from 15 to 50 years. Three patients were women, and 5 had preexisting medical conditions. Diffuse alveolar damage (DAD) was present in 5 cases (as evidenced by hyaline membrane formation, alveolo-capillary wall thickening and PMN infiltrates), and interstitial fibrosis in one case. In the fluorescence studies there were signs of oxygen radical generation, increased NOS2 protein and protein nitration in lung tissue samples, regardless of the duration of ICU admission. Viral NP was found in lung tissue samples from three patients. Type I pneumocytes and macrophages harbored viral NP, as evidenced by confocal immunofluorescence microscopy. CONCLUSIONS: Lung tissue from patients with pandemic influenza A (H1N1) viral pneumonia shows histological findings consistent with DAD. Prolonged nitro-oxidative stress is present despite antiviral treatment. Viral proteins may remain in lung tissue for prolonged periods of time, lodged in macrophages and type I pneumocytes. |*Influenza A Virus, H1N1 Subtype/immunology/isolation & purification[MESH] |Adolescent[MESH] |Adult[MESH] |Alveolar Epithelial Cells/virology[MESH] |Antiviral Agents/therapeutic use[MESH] |Consensus Sequence[MESH] |Cross Reactions[MESH] |Fatal Outcome[MESH] |Female[MESH] |Humans[MESH] |Influenza A Virus, H3N2 Subtype/immunology[MESH] |Influenza, Human/complications/drug therapy/*pathology/virology[MESH] |Lung/*pathology/virology[MESH] |Macrophages/virology[MESH] |Male[MESH] |Microscopy, Confocal[MESH] |Middle Aged[MESH] |Nitric Oxide Synthase Type II/analysis[MESH] |Nucleocapsid Proteins[MESH] |Oxidative Stress[MESH] |Pregnancy[MESH] |Pregnancy Complications, Infectious/pathology/virology[MESH] |RNA-Binding Proteins/analysis/immunology[MESH] |Respiration, Artificial[MESH] |Respiratory Distress Syndrome/etiology/mortality/pathology/therapy/virology[MESH] |Tyrosine/analogs & derivatives/analysis[MESH] |Viral Core Proteins/analysis/immunology[MESH]Lung histopathological findings in fatal pandemic influenza A (H1N1) (epmc).pdf DeepDyve Pubget Overpricing