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10.1097/00004872-199006002-00005 http://scihub22266oqcxt.onion/10.1097/00004872-199006002-00005 2213284!ä!2213284 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Hypertens+Suppl 1990 ; 8 (2): S23-32 Nephropedia Template TP {{tp|p=2213284|t=1990. The cardiotoxicity of thiazide diuretics: review of the evidence |pdf=|usr=}}{{2213284}} gab.com Text The cardiotoxicity of thiazide diuretics: review of the evidence JO: J Hypertens Suppl http://www.kidney.de/pget.php?&tw=1&pmid=2213284 #FOAvip Careful consideration of all relevant scientific evidence and a critical assessment of data quality show that thiazide diuretics are not cardiotoxic. Of 12 reported trials only two recorded more coronary heart disease events in thiazide-treated patients than in controls. One of these two was a subgroup of a larger study (Heart Attack Prevention in Primary Hypertension, HAPPHY) which found no difference between thiazide-treated and beta-blocker-treated patients. The other, the Oslo study, was too small to allow valid conclusions. Results from a subgroup in the Multiple Risk Factor Intervention Trial (MRFIT) that appeared to supply evidence for thiazide-related cardiotoxicity are suspect when examined critically. Further evidence from 24- to 28-h ECG monitoring does not support the hypothesis that thiazide diuretics, either in the presence or absence of hypokalemia, increase the frequency or severity of ventricular arrhythmias. Reports of a thiazide-induced intracellular magnesium deficiency as a cause of ventricular arrhythmias have also not been confirmed; the development of arrhythmias in acute myocardial infarction appears to be due to an increase in catecholamine levels rather than hypokalemia. There appears to be little evidence to support the assumption that long-term use of thiazide diuretics aggravates or accelerates atherosclerosis of the coronary arteries; any fall in serum cholesterol appears to be transient. For the great majority of patients with uncomplicated hypertension, without a previous myocardial infarction, congestive heart failure, diabetes mellitus or gout, thiazide diuretics appear to be both safe and effective antihypertensive agents. Twit Text FOAVip The cardiotoxicity of thiazide diuretics: review of the evidence ????J Hypertens Suppl http://www.kidney.de/pget.php?&tw=1&pmid=2213284 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=2213284 #FOAvip English Wikipedia <ref>{{Cite pmid|2213284}}</ref> The cardiotoxicity of thiazide diuretics: review of the evidence #MMPMID2213284 Freis ED J Hypertens Suppl 1990[Jun]; 8 (2): S23-32 PMID2213284show ga Careful consideration of all relevant scientific evidence and a critical assessment of data quality show that thiazide diuretics are not cardiotoxic. Of 12 reported trials only two recorded more coronary heart disease events in thiazide-treated patients than in controls. One of these two was a subgroup of a larger study (Heart Attack Prevention in Primary Hypertension, HAPPHY) which found no difference between thiazide-treated and beta-blocker-treated patients. The other, the Oslo study, was too small to allow valid conclusions. Results from a subgroup in the Multiple Risk Factor Intervention Trial (MRFIT) that appeared to supply evidence for thiazide-related cardiotoxicity are suspect when examined critically. Further evidence from 24- to 28-h ECG monitoring does not support the hypothesis that thiazide diuretics, either in the presence or absence of hypokalemia, increase the frequency or severity of ventricular arrhythmias. Reports of a thiazide-induced intracellular magnesium deficiency as a cause of ventricular arrhythmias have also not been confirmed; the development of arrhythmias in acute myocardial infarction appears to be due to an increase in catecholamine levels rather than hypokalemia. There appears to be little evidence to support the assumption that long-term use of thiazide diuretics aggravates or accelerates atherosclerosis of the coronary arteries; any fall in serum cholesterol appears to be transient. For the great majority of patients with uncomplicated hypertension, without a previous myocardial infarction, congestive heart failure, diabetes mellitus or gout, thiazide diuretics appear to be both safe and effective antihypertensive agents. |*Benzothiadiazines[MESH] |Arrhythmias, Cardiac/chemically induced[MESH] |Cholesterol/blood[MESH] |Coronary Disease/*chemically induced[MESH] |Death, Sudden/etiology[MESH] |Diuretics[MESH] |Electrocardiography, Ambulatory[MESH] |Humans[MESH] |Hypertension/*drug therapy[MESH] |Magnesium/metabolism[MESH] |Myocardial Infarction/chemically induced[MESH]The cardiotoxicity of thiazide diuretics: review of the evidence (epmc).pdf DeepDyve Pubget Overpricing