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10.1007/s10753-011-9399-0

http://scihub22266oqcxt.onion/10.1007/s10753-011-9399-0
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22038065!ä!22038065

suck abstract from ncbi


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pmid22038065      Inflammation 2012 ; 35 (3): 959-66
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  • Chlorophyll revisited: anti-inflammatory activities of chlorophyll a and inhibition of expression of TNF-alpha gene by the same #MMPMID22038065
  • Subramoniam A; Asha VV; Nair SA; Sasidharan SP; Sureshkumar PK; Rajendran KN; Karunagaran D; Ramalingam K
  • Inflammation 2012[Jun]; 35 (3): 959-66 PMID22038065show ga
  • In view of the folklore use of green leaves to treat inflammation, the anti-inflammatory property of chlorophylls and their degradation products were studied. Chlorophyll a and pheophytin a (magnesium-free chlorophyll a) from fresh leaves showed potent anti-inflammatory activity against carrageenan-induced paw edema in mice and formalin-induced paw edema in rats. Chlorophyll a inhibited bacterial lipopolysaccharide-induced TNF-alpha (a pro-inflammatory cytokine) gene expression in HEK293 cells, but it did not influence the expression of inducible nitric acid synthase and cyclooxygenase-2 genes. Chlorophyll b only marginally inhibited both inflammation and TNF-alpha gene expression. But both chlorophyll a and chlorophyll b showed the same level of marginal inhibition on 12-O-tetradecanoyl-phorbol-13-acetate-induced NF-kappaB activation. Chlorophylls and pheophytins showed in vitro anti-oxidant activity. The study shows that chlorophyll a and its degradation products are valuable and abundantly available anti-inflammatory agents and promising for the development of phytomedicine or conventional medicine to treat inflammation and related diseases.
  • |Animals[MESH]
  • |Anti-Inflammatory Agents, Non-Steroidal/*pharmacology/therapeutic use[MESH]
  • |Carrageenan[MESH]
  • |Chlorophyll A[MESH]
  • |Chlorophyll/*pharmacology/therapeutic use[MESH]
  • |Chromolaena[MESH]
  • |Cyclooxygenase 2/metabolism[MESH]
  • |Edema/drug therapy[MESH]
  • |Eupatorium[MESH]
  • |Formaldehyde[MESH]
  • |HEK293 Cells[MESH]
  • |Humans[MESH]
  • |Inflammation/*drug therapy[MESH]
  • |Lipopolysaccharides/immunology[MESH]
  • |Mice[MESH]
  • |Moraceae[MESH]
  • |NF-kappa B/biosynthesis[MESH]
  • |Nitric Oxide Synthase Type II/metabolism[MESH]
  • |Pheophytins/*pharmacology/therapeutic use[MESH]
  • |Plant Extracts/*pharmacology/therapeutic use[MESH]
  • |Rats[MESH]
  • |Rats, Wistar[MESH]
  • |Tetradecanoylphorbol Acetate/pharmacology[MESH]


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