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10.1016/j.yexcr.2011.10.013

http://scihub22266oqcxt.onion/10.1016/j.yexcr.2011.10.013
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22036650!ä!22036650

suck abstract from ncbi


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pmid22036650      Exp+Cell+Res 2012 ; 318 (2): 152-9
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  • Increased glyoxalase I levels inhibit accumulation of oxidative stress and an advanced glycation end product in mouse mesangial cells cultured in high glucose #MMPMID22036650
  • Kim KM; Kim YS; Jung DH; Lee J; Kim JS
  • Exp Cell Res 2012[Jan]; 318 (2): 152-9 PMID22036650show ga
  • Chronic high glucose levels lead to the formation of advanced glycation end-products (AGEs) as well as AGE precursors, such as methylglyoxal (MG) and glyoxal, via non-enzymatic glycation reactions in patients with diabetic mellitus. Glyoxalase 1 (GLO-1) detoxifies reactive dicarbonyls that form AGEs. To investigate the interaction between AGEs and GLO-1 in mesangial cells (MCs) under diabetic conditions, AGE levels and markers of oxidative stress were measured in GLO-1-overexpressing MCs (GLO-1-MCs) cultured in high glucose. Furthermore, we also examined levels of high glucose-induced apoptosis in GLO-1-MCs. In glomerular MCs, high glucose levels increased the formation of both MG and argpyrimidine (an MG-derived adduct) as well as GLO-1 expression. GLO-1-MCs had lower intracellular levels of MG accumulation, 8-hydroxy-deoxyguanosine (an oxidative DNA damage marker), 4-hydroxyl-2-nonenal (a lipid peroxidation product), and nitrosylated protein (a marker of oxidative-nitrosative stress) compared to control cells. Expression of mitochondrial oxidative phosphorylation complexes I, II, and III was also decreased in GLO-1-MCs. Furthermore, fewer GLO-1-MCs showed evidence of apoptosis as determined by terminal deoxynucleotidyl transferase-mediated dUTP nick labeling assay, and activation of both poly (ADP-ribose) polymerase 1 cleavage and caspase-3 was lower in GLO-1-MCs than in control cells cultured in high glucose. These results suggest that GLO-1 plays a role in high glucose-mediated signaling by reducing MG accumulation and oxidative stress in diabetes mellitus.
  • |*Oxidative Stress[MESH]
  • |8-Hydroxy-2'-Deoxyguanosine[MESH]
  • |Aldehydes/analysis[MESH]
  • |Animals[MESH]
  • |Apoptosis[MESH]
  • |Caspase 3/metabolism[MESH]
  • |Cell Line[MESH]
  • |Cells, Cultured[MESH]
  • |Deoxyguanosine/analogs & derivatives/analysis[MESH]
  • |Diabetes Mellitus/metabolism[MESH]
  • |Glycation End Products, Advanced/*metabolism[MESH]
  • |Hyperglycemia/*metabolism[MESH]
  • |Lactoylglutathione Lyase/*metabolism[MESH]
  • |Lipid Peroxidation[MESH]
  • |Mesangial Cells/*metabolism[MESH]
  • |Mice[MESH]
  • |Mitochondria/metabolism[MESH]
  • |Ornithine/analogs & derivatives/biosynthesis[MESH]
  • |Poly (ADP-Ribose) Polymerase-1[MESH]
  • |Poly(ADP-ribose) Polymerases/metabolism[MESH]
  • |Pyrimidines/biosynthesis[MESH]


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