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10.1186/1471-2202-12-106 http://scihub22266oqcxt.onion/10.1186/1471-2202-12-106 22029666/?report=reader!3217907!22029666     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Neurosci 2011 ; 12 (ä): 106 Nephropedia Template TP {{tp|p=22029666|t=2011. Effects of collagen-induced rheumatoid arthritis on amyloidosis and microvascular pathology in APP/PS1 mice |pdf=|usr=}}{{22029666}} gab.com Text Effects of collagen-induced rheumatoid arthritis on amyloidosis and microvascular pathology in APP/PS1 mice JO: BMC Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=22029666 #FOAvip BACKGROUND: Evidence suggests that rheumatoid arthritis (RA) may enhance or reduce the progression of Alzheimer's disease (AD). The present study was performed to directly explore the effects of collagen-induced rheumatoid arthritis (CIA) on amyloid plaque formation, microglial activation, and microvascular pathology in the cortex and hippocampus of the double transgenic APP/PS1 mouse model for AD. Wild-type or APP/PS1 mice that received type II collagen (CII) in complete Freund's adjuvant (CFA) at 2 months of age revealed characteristics of RA, such as joint swelling, synovitis, and cartilage and bone degradation 4 months later. Joint pathology was accompanied by sustained induction of IL-1beta and TNF-alpha in plasma over 4 weeks after administration of CII in CFA. RESULTS: CIA reduced levels of soluble and insoluble amyloid beta (Abeta) peptides and amyloid plaque formation in the cortex and hippocampus of APP/PS1 mice, which correlated with increased blood brain barrier disruption, Iba-1-positive microglia, and CD45-positive microglia/macrophages. In contrast, CIA reduced vessel density and length with features of microvascular pathology, including vascular segments, thinner vessels, and atrophic string vessels. CONCLUSIONS: The present findings suggest that RA may exert beneficial effects against Abeta burden and harmful effects on microvascular pathology in AD. Twit Text FOAVip Effects of collagen-induced rheumatoid arthritis on amyloidosis and microvascular pathology in APP/PS1 mice ????BMC Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=22029666 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22029666 #FOAvip English Wikipedia <ref>{{Cite pmid|22029666}}</ref> Effects of collagen-induced rheumatoid arthritis on amyloidosis and microvascular pathology in APP/PS1 mice #MMPMID22029666 Park SM; Shin JH; Moon GJ; Cho SI; Lee YB; Gwag BJ BMC Neurosci 2011[Oct]; 12 (ä): 106 PMID22029666show ga BACKGROUND: Evidence suggests that rheumatoid arthritis (RA) may enhance or reduce the progression of Alzheimer's disease (AD). The present study was performed to directly explore the effects of collagen-induced rheumatoid arthritis (CIA) on amyloid plaque formation, microglial activation, and microvascular pathology in the cortex and hippocampus of the double transgenic APP/PS1 mouse model for AD. Wild-type or APP/PS1 mice that received type II collagen (CII) in complete Freund's adjuvant (CFA) at 2 months of age revealed characteristics of RA, such as joint swelling, synovitis, and cartilage and bone degradation 4 months later. Joint pathology was accompanied by sustained induction of IL-1beta and TNF-alpha in plasma over 4 weeks after administration of CII in CFA. RESULTS: CIA reduced levels of soluble and insoluble amyloid beta (Abeta) peptides and amyloid plaque formation in the cortex and hippocampus of APP/PS1 mice, which correlated with increased blood brain barrier disruption, Iba-1-positive microglia, and CD45-positive microglia/macrophages. In contrast, CIA reduced vessel density and length with features of microvascular pathology, including vascular segments, thinner vessels, and atrophic string vessels. CONCLUSIONS: The present findings suggest that RA may exert beneficial effects against Abeta burden and harmful effects on microvascular pathology in AD. |*Disease Models, Animal[MESH] |*Microcirculation/genetics[MESH] |Alzheimer Disease/genetics/*pathology/physiopathology[MESH] |Amyloid beta-Protein Precursor/*genetics[MESH] |Amyloidosis/genetics/*pathology/physiopathology[MESH] |Animals[MESH] |Arthritis, Experimental/genetics/*pathology/physiopathology[MESH] |Arthritis, Rheumatoid/genetics/*pathology/physiopathology[MESH] |Collagen Type II/toxicity[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred Strains[MESH] |Mice, Transgenic[MESH]Effects of collagen-induced rheumatoid arthritis on amyloidosis and mi(epmc).pdf DeepDyve Pubget Overpricing