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10.1002/jcb.23412 http://scihub22266oqcxt.onion/10.1002/jcb.23412 22021094!7166870!22021094     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Biochem 2012 ; 113 (3): 841-7 Nephropedia Template TP {{tp|p=22021094|t=2012. Interferons induce the expression of IFITM1 and IFITM3 and suppress the proliferation of rat neonatal cardiomyocytes |pdf=|usr=}}{{22021094}} gab.com Text Interferons induce the expression of IFITM1 and IFITM3 and suppress the proliferation of rat neonatal cardiomyocytes JO: J Cell Biochem http://www.kidney.de/pget.php?&tw=1&pmid=22021094 #FOAvip Cardiovascular diseases have been one of the leading killers among the human population worldwide. During the heart development, cardiomyocytes undergo a transition from hyperplastic to hypertrophic growth with an unclear underlying mechanism. In this study, we aim to investigate how interferons differentially stimulate the interferon-inducible transmembrane (IFITM) family proteins and further be involved in the process of heart development. The expression levels of three IFITM family members, IFITM1, IFITM2, and IFITM3 were investigated during Sprague-Dawley rat myocardial development and differentiation of H9C2 cardiomyocytes. The effects of interferon-alpha, -beta, and -gamma on DNA synthesis in H9C2 cells were also characterized. Up-regulation of IFITM1 and IFITM3 were observed during the heart development of Sprague-Dawley rat and the differentiation of H9C2 cells. Moreover, interferon-alpha and -beta induce the expression of IFITM3 while interferon-gamma up-regulates IFITM1. Finally, interferon-alpha and -beta were demonstrated to inhibit DNA synthesis during H9C2 cell differentiation. Our results indicated interferons are potentially involved in the differentiation and cell proliferation during heart development. Twit Text FOAVip Interferons induce the expression of IFITM1 and IFITM3 and suppress the proliferation of rat neonatal cardiomyocytes ????J Cell Biochem http://www.kidney.de/pget.php?&tw=1&pmid=22021094 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22021094 #FOAvip English Wikipedia <ref>{{Cite pmid|22021094}}</ref> Interferons induce the expression of IFITM1 and IFITM3 and suppress the proliferation of rat neonatal cardiomyocytes #MMPMID22021094 Lau SL; Yuen ML; Kou CY; Au KW; Zhou J; Tsui SK J Cell Biochem 2012[Mar]; 113 (3): 841-7 PMID22021094show ga Cardiovascular diseases have been one of the leading killers among the human population worldwide. During the heart development, cardiomyocytes undergo a transition from hyperplastic to hypertrophic growth with an unclear underlying mechanism. In this study, we aim to investigate how interferons differentially stimulate the interferon-inducible transmembrane (IFITM) family proteins and further be involved in the process of heart development. The expression levels of three IFITM family members, IFITM1, IFITM2, and IFITM3 were investigated during Sprague-Dawley rat myocardial development and differentiation of H9C2 cardiomyocytes. The effects of interferon-alpha, -beta, and -gamma on DNA synthesis in H9C2 cells were also characterized. Up-regulation of IFITM1 and IFITM3 were observed during the heart development of Sprague-Dawley rat and the differentiation of H9C2 cells. Moreover, interferon-alpha and -beta induce the expression of IFITM3 while interferon-gamma up-regulates IFITM1. Finally, interferon-alpha and -beta were demonstrated to inhibit DNA synthesis during H9C2 cell differentiation. Our results indicated interferons are potentially involved in the differentiation and cell proliferation during heart development. |Animals[MESH] |Animals, Newborn[MESH] |Antigens, Differentiation/*biosynthesis/genetics[MESH] |Cell Differentiation[MESH] |Cell Line[MESH] |Cell Proliferation[MESH] |DNA/biosynthesis[MESH] |Heart/growth & development[MESH] |Interferons/*pharmacology[MESH] |Membrane Proteins/*biosynthesis/genetics[MESH] |Myocytes, Cardiac/cytology/drug effects/*metabolism[MESH] |Proliferating Cell Nuclear Antigen/analysis[MESH] |RNA, Messenger/metabolism[MESH] |Rats[MESH]Interferons induce the expression of IFITM1 and IFITM3 and suppress th(epmc).pdf DeepDyve Pubget Overpricing