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10.1093/infdis/jir665 http://scihub22266oqcxt.onion/10.1093/infdis/jir665 22013225!ä!22013225 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Infect+Dis 2011 ; 204 (12): 1866-78 Nephropedia Template TP {{tp|p=22013225|t=2011. H5N1 influenza virus-induced mediators upregulate RIG-I in uninfected cells by paracrine effects contributing to amplified cytokine cascades |pdf=|usr=}}{{22013225}} gab.com Text H5N1 influenza virus-induced mediators upregulate RIG-I in uninfected cells by paracrine effects contributing to amplified cytokine cascades JO: J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=22013225 #FOAvip Highly pathogenic avian influenza H5N1 viruses cause severe disease in humans, and dysregulation of cytokine responses is believed to contribute to the pathogenesis of human H5N1 disease. However, mechanisms leading to the increased induction of proinflammatory cytokines by H5N1 viruses are poorly understood. We show that the innate sensing receptor RIG-I is involved in interferon regulatory factor 3 (IRF3), NF-kappaB nuclear translocation, p38 activation, and the subsequent interferon (IFN) beta, IFN-lambda1, and tumor necrosis factor alpha induction during H5N1 infection. Soluble mediators from H5N1-infected human macrophages upregulate RIG-I, MDA5, and TLR3 to much higher levels than those from seasonal H1N1 in uninfected human macrophages and alveolar epithelial cells via paracrine IFNAR1/JAK but not IFN-lambda receptor signaling. Compared with H1N1 virus-induced mediators, H5N1 mediators markedly enhance the cytokine response to PolyIC and to both seasonal and H5N1 virus infection in a RIG-I-dependent manner. Thus, sensitizing neighboring cells by upregulation of RIG-I contributes to the amplified cytokine cascades during H5N1 infection. Twit Text FOAVip H5N1 influenza virus-induced mediators upregulate RIG-I in uninfected cells by paracrine effects contributing to amplified cytokine cascades ????J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=22013225 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22013225 #FOAvip English Wikipedia <ref>{{Cite pmid|22013225}}</ref> H5N1 influenza virus-induced mediators upregulate RIG-I in uninfected cells by paracrine effects contributing to amplified cytokine cascades #MMPMID22013225 Hui KP; Lee SM; Cheung CY; Mao H; Lai AK; Chan RW; Chan MC; Tu W; Guan Y; Lau YL; Peiris JS J Infect Dis 2011[Dec]; 204 (12): 1866-78 PMID22013225show ga Highly pathogenic avian influenza H5N1 viruses cause severe disease in humans, and dysregulation of cytokine responses is believed to contribute to the pathogenesis of human H5N1 disease. However, mechanisms leading to the increased induction of proinflammatory cytokines by H5N1 viruses are poorly understood. We show that the innate sensing receptor RIG-I is involved in interferon regulatory factor 3 (IRF3), NF-kappaB nuclear translocation, p38 activation, and the subsequent interferon (IFN) beta, IFN-lambda1, and tumor necrosis factor alpha induction during H5N1 infection. Soluble mediators from H5N1-infected human macrophages upregulate RIG-I, MDA5, and TLR3 to much higher levels than those from seasonal H1N1 in uninfected human macrophages and alveolar epithelial cells via paracrine IFNAR1/JAK but not IFN-lambda receptor signaling. Compared with H1N1 virus-induced mediators, H5N1 mediators markedly enhance the cytokine response to PolyIC and to both seasonal and H5N1 virus infection in a RIG-I-dependent manner. Thus, sensitizing neighboring cells by upregulation of RIG-I contributes to the amplified cytokine cascades during H5N1 infection. |*Signal Transduction[MESH] |Adaptor Proteins, Signal Transducing/genetics/immunology/*metabolism[MESH] |Cells, Cultured[MESH] |Cytokines/*metabolism[MESH] |DEAD Box Protein 58[MESH] |DEAD-box RNA Helicases/genetics/immunology/*metabolism[MESH] |Epithelial Cells/immunology/metabolism[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Influenza A Virus, H1N1 Subtype/genetics/immunology[MESH] |Influenza A Virus, H5N1 Subtype/genetics/*immunology[MESH] |Influenza, Human/immunology/*metabolism/virology[MESH] |Interferon Regulatory Factor-3/metabolism[MESH] |Interferon-Induced Helicase, IFIH1[MESH] |Janus Kinases/immunology[MESH] |Macrophages/immunology/*metabolism[MESH] |NF-kappa B/metabolism[MESH] |Paracrine Communication/*immunology[MESH] |Pulmonary Alveoli/immunology/metabolism[MESH] |RNA, Small Interfering/genetics[MESH] |RNA, Viral/metabolism[MESH] |Receptor, Interferon alpha-beta/immunology[MESH] |Receptors, Immunologic[MESH] |Toll-Like Receptor 3/metabolism[MESH] |Up-Regulation[MESH]H5N1 influenza virus-induced mediators upregulate RIG-I in uninfected (epmc).pdf DeepDyve Pubget Overpricing