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10.1152/ajpheart.00453.2011 http://scihub22266oqcxt.onion/10.1152/ajpheart.00453.2011 21984552!ä!21984552 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21984552&cmd=llinks): Failed to open stream: HTTP request failed! 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Short-term magnesium deficiency upregulates ceramide synthase in cardiovascular tissues and cells: cross-talk among cytokines, Mg2+, NF-kappaB, and de novo ceramide |pdf=|usr=}}{{21984552}} gab.com Text Short-term magnesium deficiency upregulates ceramide synthase in cardiovascular tissues and cells: cross-talk among cytokines, Mg2+, NF-kappaB, and de novo ceramide JO: Am J Physiol Heart Circ Physiol http://www.kidney.de/pget.php?&tw=1&pmid=21984552 #FOAvip The present study tested the hypotheses that 1) short-term dietary deficiency (MgD) of magnesium (21 days) would result in the upregulation of ceramide synthase (CS) in left ventricular (LV), right ventricular, atrial, and aortic smooth muscle, as well as induce a synthesis/release of select cytokines and chemokines into the LV and aortic smooth muscle and serum; 2) exposure of primary cultured vascular smooth muscle cells (VSMCs) to low extracellular Mg concentration would lead to the synthesis/release of select cytokines/chemokines, activation of N-SMase, and the de novo synthesis of ceramide; and 3) inhibition of CS by fumonisin B1 (FB1) or inhibition of neutral sphingomyelinase (N-SMase) by scyphostatin (SCY) in VSMCs exposed to low Mg would result in reductions in the levels of the cytokines/chemokines and lowered levels of ceramide concomitant with inhibition of NF-kappaB activation. The data indicated that short-term MgD (10% normal dietary intake) resulted in the upregulation of CS in ventricular, atrial, and aortic smooth muscles coupled to the synthesis/release of 12 different cytokines/chemokines, as well as activation of NF-kappaB in the LV and aortic smooth muscle and sera; even very low levels of water-borne Mg (e.g., 15 mg.l(-1).day(-1)) either prevented or ameliorated the upregulation and synthesis of the cytokines/chemokines. Our experiments also showed that VSMCs exposed to low extracellular Mg resulted in the synthesis of 5 different cytokines and chemokines concomitant with synthesis/release of ceramide. However, inhibition of the synthesis and release of ceramide by either FB1 or SCY attenuated, markedly , the generation of ceramide, release of the cytokines/chemokines, and activation of NF-kappaB (as measured by activated p65 and cRel). Twit Text FOAVip Short-term magnesium deficiency upregulates ceramide synthase in cardiovascular tissues and cells: cross-talk among cytokines, Mg2+, NF-kappaB, and de novo ceramide ????Am J Physiol Heart Circ Physiol http://www.kidney.de/pget.php?&tw=1&pmid=21984552 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21984552 #FOAvip English Wikipedia <ref>{{Cite pmid|21984552}}</ref> Short-term magnesium deficiency upregulates ceramide synthase in cardiovascular tissues and cells: cross-talk among cytokines, Mg2+, NF-kappaB, and de novo ceramide #MMPMID21984552 Altura BM; Shah NC; Shah G; Zhang A; Li W; Zheng T; Perez-Albela JL; Altura BT Am J Physiol Heart Circ Physiol 2012[Jan]; 302 (1): H319-32 PMID21984552show ga The present study tested the hypotheses that 1) short-term dietary deficiency (MgD) of magnesium (21 days) would result in the upregulation of ceramide synthase (CS) in left ventricular (LV), right ventricular, atrial, and aortic smooth muscle, as well as induce a synthesis/release of select cytokines and chemokines into the LV and aortic smooth muscle and serum; 2) exposure of primary cultured vascular smooth muscle cells (VSMCs) to low extracellular Mg concentration would lead to the synthesis/release of select cytokines/chemokines, activation of N-SMase, and the de novo synthesis of ceramide; and 3) inhibition of CS by fumonisin B1 (FB1) or inhibition of neutral sphingomyelinase (N-SMase) by scyphostatin (SCY) in VSMCs exposed to low Mg would result in reductions in the levels of the cytokines/chemokines and lowered levels of ceramide concomitant with inhibition of NF-kappaB activation. The data indicated that short-term MgD (10% normal dietary intake) resulted in the upregulation of CS in ventricular, atrial, and aortic smooth muscles coupled to the synthesis/release of 12 different cytokines/chemokines, as well as activation of NF-kappaB in the LV and aortic smooth muscle and sera; even very low levels of water-borne Mg (e.g., 15 mg.l(-1).day(-1)) either prevented or ameliorated the upregulation and synthesis of the cytokines/chemokines. Our experiments also showed that VSMCs exposed to low extracellular Mg resulted in the synthesis of 5 different cytokines and chemokines concomitant with synthesis/release of ceramide. However, inhibition of the synthesis and release of ceramide by either FB1 or SCY attenuated, markedly , the generation of ceramide, release of the cytokines/chemokines, and activation of NF-kappaB (as measured by activated p65 and cRel). |Amides/pharmacology[MESH] |Animals[MESH] |Aorta/metabolism[MESH] |Cells, Cultured[MESH] |Ceramides/*metabolism[MESH] |Cytokines/*metabolism[MESH] |Diet[MESH] |Disease Models, Animal[MESH] |Drinking[MESH] |Eating[MESH] |Enzyme Inhibitors/pharmacology[MESH] |Female[MESH] |Fumonisins/pharmacology[MESH] |Heart Atria/enzymology[MESH] |Heart Ventricles/enzymology[MESH] |Magnesium Deficiency/*enzymology/prevention & control[MESH] |Magnesium/administration & dosage/*metabolism[MESH] |Male[MESH] |Muscle, Smooth, Vascular/drug effects/*enzymology[MESH] |Myocytes, Cardiac/drug effects/*enzymology[MESH] |NF-kappa B/*metabolism[MESH] |Oxidoreductases/antagonists & inhibitors/*metabolism[MESH] |Proto-Oncogene Proteins c-rel/metabolism[MESH] |Pyrones/pharmacology[MESH] |Rats[MESH] |Regression Analysis[MESH] |Signal Transduction[MESH] |Sphingomyelin Phosphodiesterase/antagonists & inhibitors/metabolism[MESH] |Time Factors[MESH] |Transcription Factor RelA/metabolism[MESH]Short-term magnesium deficiency upregulates ceramide synthase in cardi(epmc).pdf DeepDyve Pubget Overpricing