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10.1684/mrh.2011.0289 http://scihub22266oqcxt.onion/10.1684/mrh.2011.0289 21983221!ä!21983221 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Magnes+Res 2011 ; 24 (3): S101-8 Nephropedia Template TP {{tp|p=21983221|t=2011. Role of the distal convoluted tubule in renal Mg2+ handling: molecular lessons from inherited hypomagnesemia |pdf=|usr=}}{{21983221}} gab.com Text Role of the distal convoluted tubule in renal Mg2+ handling: molecular lessons from inherited hypomagnesemia JO: Magnes Res http://www.kidney.de/pget.php?&tw=1&pmid=21983221 #FOAvip In healthy individuals, Mg(2+) homeostasis is tightly regulated by the concerted action of intestinal absorption, exchange with bone, and renal excretion. The kidney, more precisely the distal convoluted tubule (DCT), is the final determinant of plasma Mg(2+) concentrations. Positional cloning strategies in families with hereditary hypomagnesemia identified defects in several proteins localized in the DCT as causative factors. So far, the identified actors involved in Mg(2+) handling in the DCT include: the transient receptor potential channel melastatin member 6, the pro-epidermal growth factor, the thiazide-sensitive Na(+)-Cl(-) cotransporter, the gamma-subunit of the Na(+)/K(+)-ATPase, the hepatocyte nuclear factor 1B, the potassium channels Kv1.1 and Kir4.1, and the cyclin M2. In the years to come, the identification of new magnesiotropic genes and related proteins will further clarify the role of the kidney in Mg(2+) homeostasis, and will potentially lead to new therapeutic approaches for hypomagnesemia. Twit Text FOAVip Role of the distal convoluted tubule in renal Mg2+ handling: molecular lessons from inherited hypomagnesemia ????Magnes Res http://www.kidney.de/pget.php?&tw=1&pmid=21983221 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21983221 #FOAvip English Wikipedia <ref>{{Cite pmid|21983221}}</ref> Role of the distal convoluted tubule in renal Mg2+ handling: molecular lessons from inherited hypomagnesemia #MMPMID21983221 Ferre S; Hoenderop JJ; Bindels RJ Magnes Res 2011[Sep]; 24 (3): S101-8 PMID21983221show ga In healthy individuals, Mg(2+) homeostasis is tightly regulated by the concerted action of intestinal absorption, exchange with bone, and renal excretion. The kidney, more precisely the distal convoluted tubule (DCT), is the final determinant of plasma Mg(2+) concentrations. Positional cloning strategies in families with hereditary hypomagnesemia identified defects in several proteins localized in the DCT as causative factors. So far, the identified actors involved in Mg(2+) handling in the DCT include: the transient receptor potential channel melastatin member 6, the pro-epidermal growth factor, the thiazide-sensitive Na(+)-Cl(-) cotransporter, the gamma-subunit of the Na(+)/K(+)-ATPase, the hepatocyte nuclear factor 1B, the potassium channels Kv1.1 and Kir4.1, and the cyclin M2. In the years to come, the identification of new magnesiotropic genes and related proteins will further clarify the role of the kidney in Mg(2+) homeostasis, and will potentially lead to new therapeutic approaches for hypomagnesemia. |Absorption[MESH] |Biological Transport[MESH] |Humans[MESH] |Kidney Tubules, Distal/*metabolism[MESH] |Magnesium/*metabolism[MESH]Role of the distal convoluted tubule in renal Mg2+ handling: molecular(epmc).pdf DeepDyve Pubget Overpricing