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10.1371/journal.pone.0025242 http://scihub22266oqcxt.onion/10.1371/journal.pone.0025242 21966467!3179470!21966467     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21966467&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       PLoS+One 2011 ; 6 (9): e25242 Nephropedia Template TP {{tp|p=21966467|t=2011. Increased MDSC accumulation and Th2 biased response to influenza A virus infection in the absence of TLR7 in mice |pdf=|usr=}}{{21966467}} gab.com Text Increased MDSC accumulation and Th2 biased response to influenza A virus infection in the absence of TLR7 in mice JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=21966467 #FOAvip Toll-like receptors (TLRs) play an important role in the induction of innate and adaptive immune response against influenza A virus (IAV) infection; however, the role of Toll-like receptor 7 (TLR7) during the innate immune response to IAV infection and the cell types affected by the absence of TLR7 are not clearly understood. In this study, we show that myeloid derived suppressor cells (MDSC) accumulate in the lungs of TLR7 deficient mice more so than in wild-type C57Bl/6 mice, and display increased cytokine expression. Furthermore, there is an increase in production of Th2 cytokines by TLR7(-/-) compared with wildtype CD4+ T-cells in vivo, leading to a Th2 polarized humoral response. Our findings indicate that TLR7 modulates the accumulation of MDSCs during an IAV infection in mice, and that lack of TLR7 signaling leads to a Th2-biased response. Twit Text FOAVip Increased MDSC accumulation and Th2 biased response to influenza A virus infection in the absence of TLR7 in mice ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=21966467 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21966467 #FOAvip English Wikipedia <ref>{{Cite pmid|21966467}}</ref> Increased MDSC accumulation and Th2 biased response to influenza A virus infection in the absence of TLR7 in mice #MMPMID21966467 Jeisy-Scott V; Davis WG; Patel JR; Bowzard JB; Shieh WJ; Zaki SR; Katz JM; Sambhara S PLoS One 2011[]; 6 (9): e25242 PMID21966467show ga Toll-like receptors (TLRs) play an important role in the induction of innate and adaptive immune response against influenza A virus (IAV) infection; however, the role of Toll-like receptor 7 (TLR7) during the innate immune response to IAV infection and the cell types affected by the absence of TLR7 are not clearly understood. In this study, we show that myeloid derived suppressor cells (MDSC) accumulate in the lungs of TLR7 deficient mice more so than in wild-type C57Bl/6 mice, and display increased cytokine expression. Furthermore, there is an increase in production of Th2 cytokines by TLR7(-/-) compared with wildtype CD4+ T-cells in vivo, leading to a Th2 polarized humoral response. Our findings indicate that TLR7 modulates the accumulation of MDSCs during an IAV infection in mice, and that lack of TLR7 signaling leads to a Th2-biased response. |Animals[MESH] |CD4-Positive T-Lymphocytes[MESH] |Cytokines/metabolism[MESH] |Enzyme-Linked Immunosorbent Assay[MESH] |Flow Cytometry[MESH] |Immunity, Innate/genetics/*immunology[MESH] |Influenza A virus/*immunology[MESH] |Lung/cytology/immunology/metabolism[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Myeloid Cells/cytology[MESH] |Th2 Cells/*immunology/metabolism[MESH]Increased MDSC accumulation and Th2 biased response to influenza A vir(epmc).pdf DeepDyve Pubget Overpricing