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10.1681/ASN.2010121249 http://scihub22266oqcxt.onion/10.1681/ASN.2010121249 21921145!3279994!21921145     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Soc+Nephrol 2011 ; 22 (11): 2004-15 Nephropedia Template TP {{tp|p=21921145|t=2011. Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury |pdf=|usr=}}{{21921145}} gab.com Text Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=21921145 #FOAvip Hypoxia-inducible transcription factors (HIF) protect cells against oxygen deprivation, and HIF stabilization before ischemia mitigates tissue injury. Because ischemic acute kidney injury (AKI) often involves the thick ascending limb (TAL), modulation of HIF in this segment may be protective. Here, we generated mice with targeted TAL deletion of the von Hippel-Lindau protein (Vhl), which mediates HIF degradation under normoxia, using Tamm-Horsfall protein (Thp)-driven Cre expression. These mice showed strong expression of HIF-1alpha in TALs but no changes in kidney morphology or function under control conditions. Deficiency of Vhl in the TAL markedly attenuated proximal tubular injury and preserved TAL function following ischemia-reperfusion, which may be partially a result of enhanced expression of glycolytic enzymes and lactate metabolism. These results highlight the importance of the thick ascending limb in the pathogenesis of AKI and suggest that pharmacologically targeting the HIF system may have potential to prevent and mitigate AKI. Twit Text FOAVip Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=21921145 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21921145 #FOAvip English Wikipedia <ref>{{Cite pmid|21921145}}</ref> Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury #MMPMID21921145 Schley G; Klanke B; Schodel J; Forstreuter F; Shukla D; Kurtz A; Amann K; Wiesener MS; Rosen S; Eckardt KU; Maxwell PH; Willam C J Am Soc Nephrol 2011[Nov]; 22 (11): 2004-15 PMID21921145show ga Hypoxia-inducible transcription factors (HIF) protect cells against oxygen deprivation, and HIF stabilization before ischemia mitigates tissue injury. Because ischemic acute kidney injury (AKI) often involves the thick ascending limb (TAL), modulation of HIF in this segment may be protective. Here, we generated mice with targeted TAL deletion of the von Hippel-Lindau protein (Vhl), which mediates HIF degradation under normoxia, using Tamm-Horsfall protein (Thp)-driven Cre expression. These mice showed strong expression of HIF-1alpha in TALs but no changes in kidney morphology or function under control conditions. Deficiency of Vhl in the TAL markedly attenuated proximal tubular injury and preserved TAL function following ischemia-reperfusion, which may be partially a result of enhanced expression of glycolytic enzymes and lactate metabolism. These results highlight the importance of the thick ascending limb in the pathogenesis of AKI and suggest that pharmacologically targeting the HIF system may have potential to prevent and mitigate AKI. |Acute Kidney Injury/genetics/metabolism/*physiopathology[MESH] |Anaerobic Threshold/physiology[MESH] |Animals[MESH] |Disease Models, Animal[MESH] |Erythropoiesis/physiology[MESH] |Glycolysis/physiology[MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism[MESH] |Integrases/genetics[MESH] |Kidney/physiology[MESH] |Loop of Henle/*physiology[MESH] |Mice[MESH] |Mice, Mutant Strains[MESH] |Nephritis/genetics/metabolism/physiopathology[MESH] |Reperfusion Injury/genetics/metabolism/physiopathology[MESH] |Uromodulin/*genetics/metabolism[MESH]Hypoxia-inducible transcription factors stabilization in the thick asc(epmc).pdf DeepDyve Pubget Overpricing