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10.1161/HYPERTENSIONAHA.111.177626 http://scihub22266oqcxt.onion/10.1161/HYPERTENSIONAHA.111.177626 21896938!3174356!21896938     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Hypertension 2011 ; 58 (4): 657-64 Nephropedia Template TP {{tp|p=21896938|t=2011. Silencing of hypoxia-inducible factor-1alpha gene attenuated angiotensin II-induced renal injury in Sprague-Dawley rats |pdf=|usr=}}{{21896938}} gab.com Text Silencing of hypoxia-inducible factor-1alpha gene attenuated angiotensin II-induced renal injury in Sprague-Dawley rats JO: Hypertension http://www.kidney.de/pget.php?&tw=1&pmid=21896938 #FOAvip Although it has been shown that upregulation of hypoxia-inducible factor (HIF)-1alpha is protective in acute ischemic renal injury, long-term overactivation of HIF-1alpha is implicated to be injurious in chronic kidney diseases. Angiotensin II (Ang II) is a well-known pathogenic factor producing chronic renal injury and has also been shown to increase HIF-1alpha. However, the contribution of HIF-1alpha to Ang II-induced renal injury has not been evidenced. The present study tested the hypothesis that HIF-1alpha mediates Ang II-induced renal injury in Sprague-Dawley rats. Chronic renal injury was induced by Ang II infusion (200 ng/kg per minute) for 2 weeks in uninephrectomized rats. Transfection of vectors expressing HIF-1alpha small hairpin RNA into the kidneys knocked down HIF-1alpha gene expression by 70%, blocked Ang II-induced HIF-1alpha activation, and significantly attenuated Ang II-induced albuminuria, which was accompanied by inhibition of Ang II-induced vascular endothelial growth factor, a known glomerular permeability factor, in glomeruli. HIF-1alpha small hairpin RNA also significantly improved the glomerular morphological damage induced by Ang II. Furthermore, HIF-1alpha small hairpin RNA blocked Ang II-induced upregulation of collagen and alpha-smooth muscle actin in tubulointerstitial region. There was no difference in creatinine clearance and Ang II-induced increase in blood pressure. HIF-1alpha small hairpin RNA had no effect on Ang II-induced reduction in renal blood flow and hypoxia in the kidneys. These data suggested that overactivation of HIF-1alpha-mediated gene regulation in the kidney is a pathogenic pathway mediating Ang II-induced chronic renal injuries, and normalization of overactivated HIF-1alpha may be used as a treatment strategy for chronic kidney damages associated with excessive Ang II. Twit Text FOAVip Silencing of hypoxia-inducible factor-1alpha gene attenuated angiotensin II-induced renal injury in Sprague-Dawley rats ????Hypertension http://www.kidney.de/pget.php?&tw=1&pmid=21896938 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21896938 #FOAvip English Wikipedia <ref>{{Cite pmid|21896938}}</ref> Silencing of hypoxia-inducible factor-1alpha gene attenuated angiotensin II-induced renal injury in Sprague-Dawley rats #MMPMID21896938 Zhu Q; Wang Z; Xia M; Li PL; Van Tassell BW; Abbate A; Dhaduk R; Li N Hypertension 2011[Oct]; 58 (4): 657-64 PMID21896938show ga Although it has been shown that upregulation of hypoxia-inducible factor (HIF)-1alpha is protective in acute ischemic renal injury, long-term overactivation of HIF-1alpha is implicated to be injurious in chronic kidney diseases. Angiotensin II (Ang II) is a well-known pathogenic factor producing chronic renal injury and has also been shown to increase HIF-1alpha. However, the contribution of HIF-1alpha to Ang II-induced renal injury has not been evidenced. The present study tested the hypothesis that HIF-1alpha mediates Ang II-induced renal injury in Sprague-Dawley rats. Chronic renal injury was induced by Ang II infusion (200 ng/kg per minute) for 2 weeks in uninephrectomized rats. Transfection of vectors expressing HIF-1alpha small hairpin RNA into the kidneys knocked down HIF-1alpha gene expression by 70%, blocked Ang II-induced HIF-1alpha activation, and significantly attenuated Ang II-induced albuminuria, which was accompanied by inhibition of Ang II-induced vascular endothelial growth factor, a known glomerular permeability factor, in glomeruli. HIF-1alpha small hairpin RNA also significantly improved the glomerular morphological damage induced by Ang II. Furthermore, HIF-1alpha small hairpin RNA blocked Ang II-induced upregulation of collagen and alpha-smooth muscle actin in tubulointerstitial region. There was no difference in creatinine clearance and Ang II-induced increase in blood pressure. HIF-1alpha small hairpin RNA had no effect on Ang II-induced reduction in renal blood flow and hypoxia in the kidneys. These data suggested that overactivation of HIF-1alpha-mediated gene regulation in the kidney is a pathogenic pathway mediating Ang II-induced chronic renal injuries, and normalization of overactivated HIF-1alpha may be used as a treatment strategy for chronic kidney damages associated with excessive Ang II. |Albuminuria/chemically induced/prevention & control/urine[MESH] |Angiotensin II/*adverse effects/pharmacology[MESH] |Animals[MESH] |Blood Pressure/drug effects/physiology[MESH] |Chronic Disease[MESH] |Creatinine/urine[MESH] |Disease Models, Animal[MESH] |Gene Expression Regulation/drug effects[MESH] |Gene Silencing/drug effects/*physiology[MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/*antagonists & inhibitors/*genetics/metabolism[MESH] |Kidney Diseases/chemically induced/metabolism/*prevention & control[MESH] |Kidney Glomerulus/drug effects/metabolism/pathology[MESH] |Male[MESH] |RNA, Small Interfering/pharmacology[MESH] |Rats[MESH] |Rats, Sprague-Dawley[MESH]Silencing of hypoxia-inducible factor-1alpha gene attenuated angiotens(epmc).pdf DeepDyve Pubget Overpricing