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10.1681/ASN.2010090970 http://scihub22266oqcxt.onion/10.1681/ASN.2010090970 21719782!3137574!21719782     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Soc+Nephrol 2011 ; 22 (7): 1262-74 Nephropedia Template TP {{tp|p=21719782|t=2011. Parietal epithelial cells participate in the formation of sclerotic lesions in focal segmental glomerulosclerosis |pdf=|usr=}}{{21719782}} gab.com Text Parietal epithelial cells participate in the formation of sclerotic lesions in focal segmental glomerulosclerosis JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=21719782 #FOAvip The pathogenesis of the development of sclerotic lesions in focal segmental glomerulosclerosis (FSGS) remains unknown. Here, we selectively tagged podocytes or parietal epithelial cells (PECs) to determine whether PECs contribute to sclerosis. In three distinct models of FSGS (5/6-nephrectomy + DOCA-salt; the murine transgenic chronic Thy1.1 model; or the MWF rat) and in human biopsies, the primary injury to induce FSGS associated with focal activation of PECs and the formation of cellular adhesions to the capillary tuft. From this entry site, activated PECs invaded the affected segment of the glomerular tuft and deposited extracellular matrix. Within the affected segment, podocytes were lost and mesangial sclerosis developed within the endocapillary compartment. In conclusion, these results demonstrate that PECs contribute to the development and progression of the sclerotic lesions that define FSGS, but this pathogenesis may be relevant to all etiologies of glomerulosclerosis. Twit Text FOAVip Parietal epithelial cells participate in the formation of sclerotic lesions in focal segmental glomerulosclerosis ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=21719782 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21719782 #FOAvip English Wikipedia <ref>{{Cite pmid|21719782}}</ref> Parietal epithelial cells participate in the formation of sclerotic lesions in focal segmental glomerulosclerosis #MMPMID21719782 Smeets B; Kuppe C; Sicking EM; Fuss A; Jirak P; van Kuppevelt TH; Endlich K; Wetzels JF; Grone HJ; Floege J; Moeller MJ J Am Soc Nephrol 2011[Jul]; 22 (7): 1262-74 PMID21719782show ga The pathogenesis of the development of sclerotic lesions in focal segmental glomerulosclerosis (FSGS) remains unknown. Here, we selectively tagged podocytes or parietal epithelial cells (PECs) to determine whether PECs contribute to sclerosis. In three distinct models of FSGS (5/6-nephrectomy + DOCA-salt; the murine transgenic chronic Thy1.1 model; or the MWF rat) and in human biopsies, the primary injury to induce FSGS associated with focal activation of PECs and the formation of cellular adhesions to the capillary tuft. From this entry site, activated PECs invaded the affected segment of the glomerular tuft and deposited extracellular matrix. Within the affected segment, podocytes were lost and mesangial sclerosis developed within the endocapillary compartment. In conclusion, these results demonstrate that PECs contribute to the development and progression of the sclerotic lesions that define FSGS, but this pathogenesis may be relevant to all etiologies of glomerulosclerosis. |Animals[MESH] |Cell Lineage[MESH] |Desoxycorticosterone[MESH] |Epithelial Cells/metabolism/*pathology[MESH] |Extracellular Matrix/metabolism[MESH] |Glomerulosclerosis, Focal Segmental/*etiology/pathology[MESH] |Humans[MESH] |Hyaluronan Receptors/metabolism[MESH] |Mice[MESH] |Mice, Transgenic[MESH] |Nephrectomy[MESH] |Podocytes/*pathology[MESH] |Rats[MESH] |Sodium Chloride, Dietary[MESH]Parietal epithelial cells participate in the formation of sclerotic le(epmc).pdf DeepDyve Pubget Overpricing