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10.1016/B978-0-12-386469-7.00003-7 http://scihub22266oqcxt.onion/10.1016/B978-0-12-386469-7.00003-7 21704228/?report=reader!3175007!21704228     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Cancer+Res 2011 ; 110 (ä): 43-76 Nephropedia Template TP {{tp|p=21704228|t=2011. Chromatin insulators: a role in nuclear organization and gene expression |pdf=|usr=}}{{21704228}} gab.com Text Chromatin insulators: a role in nuclear organization and gene expression JO: Adv Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=21704228 #FOAvip Chromatin insulators are DNA-protein complexes with broad functions in nuclear biology. Based on the ability of insulator proteins to interact with each other, it was originally found that insulators form loops that bring together distant regions of the genome. Data from genome-wide localization studies indicate that insulator proteins can be present in intergenic regions as well as at the 5', introns or 3' of genes, suggesting a variety of roles for insulator loops in chromosome biology. Recent results suggest that insulators mediate intra- and interchromosomal interactions to affect transcription, imprinting, and recombination. Cells have developed mechanisms to control insulator activity by recruiting specialized proteins or by covalent modification of core components. It is then possible that insulator-mediated interactions set up cell-specific blueprints of nuclear organization that may contribute to the establishment of different patterns of gene expression during cell differentiation and development. As a consequence, disruption of insulator activity could result in the development of cancer or other disease states. Twit Text FOAVip Chromatin insulators: a role in nuclear organization and gene expression ????Adv Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=21704228 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21704228 #FOAvip English Wikipedia <ref>{{Cite pmid|21704228}}</ref> Chromatin insulators: a role in nuclear organization and gene expression #MMPMID21704228 Yang J; Corces VG Adv Cancer Res 2011[]; 110 (ä): 43-76 PMID21704228show ga Chromatin insulators are DNA-protein complexes with broad functions in nuclear biology. Based on the ability of insulator proteins to interact with each other, it was originally found that insulators form loops that bring together distant regions of the genome. Data from genome-wide localization studies indicate that insulator proteins can be present in intergenic regions as well as at the 5', introns or 3' of genes, suggesting a variety of roles for insulator loops in chromosome biology. Recent results suggest that insulators mediate intra- and interchromosomal interactions to affect transcription, imprinting, and recombination. Cells have developed mechanisms to control insulator activity by recruiting specialized proteins or by covalent modification of core components. It is then possible that insulator-mediated interactions set up cell-specific blueprints of nuclear organization that may contribute to the establishment of different patterns of gene expression during cell differentiation and development. As a consequence, disruption of insulator activity could result in the development of cancer or other disease states. |*Insulator Elements[MESH] |Animals[MESH] |Cell Nucleus/*genetics/*metabolism[MESH] |Chromatin/*genetics/*metabolism[MESH] |Gene Expression[MESH]Chromatin insulators: a role in nuclear organization and gene expressi(epmc).pdf DeepDyve Pubget Overpricing