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10.3109/17453674.2011.588854

http://scihub22266oqcxt.onion/10.3109/17453674.2011.588854
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suck abstract from ncbi


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pmid21657968      Acta+Orthop 2011 ; 82 (4): 489-93
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  • CRP and leukocyte-count after lumbar spine surgery: fusion vs nucleotomy #MMPMID21657968
  • Kraft CN; Kruger T; Westhoff J; Luring C; Weber O; Wirtz DC; Pennekamp PH
  • Acta Orthop 2011[Aug]; 82 (4): 489-93 PMID21657968show ga
  • BACKGROUND: Despite the fact that C-reactive protein (CRP) levels and white blood cell (WBC) count are routine blood chemistry parameters for the early assessment of wound infection after surgical procedures, little is known about the natural history of their serum values after major and minimally invasive spinal procedures. METHODS: Pre- and postoperative CRP serum levels and WBC count in 347 patients were retrospectively assessed after complication-free, single-level open posterior lumbar interlaminar fusion (PLIF) (n = 150) for disc degeneration and spinal stenosis and endoscopically assisted lumbar discectomy (n = 197) for herniated lumbar disc. Confounding variables such as overweight, ASA classification, arterial hypertension, diabetes mellitus, and perioperative antibiotics were recorded to evaluate their influence on the kinetics of CRP values and WBC count postoperatively. RESULTS: In both procedures, CRP peaked 2-3 days after surgery. The maximum CRP level was significantly higher after fusion: mean 127 (SD 57) (p < 0.001). A rapid fall in CRP within 4-6 days was observed for both groups, with almost normal values being reached after 14 days. Only BMI > 25 and long duration of surgery were associated with higher peak CRP values. WBC count did not show a typical and therefore interpretable profile. CONCLUSION: CRP is a predictable and responsive serum parameter in postoperative monitoring of inflammatory responses in patients undergoing spine surgery, whereas WBC kinetics is unspecific. We suggest that CRP could be measured on the day before surgery, on day 2 or 3 after surgery, and also between days 4 and 6, to aid in early detection of infectious complications.
  • |*Diskectomy, Percutaneous/adverse effects[MESH]
  • |*Leukocyte Count[MESH]
  • |*Spinal Fusion/adverse effects[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Anti-Bacterial Agents/administration & dosage[MESH]
  • |C-Reactive Protein/*analysis[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Intervertebral Disc Degeneration/surgery[MESH]
  • |Lumbar Vertebrae/*surgery[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Postoperative Period[MESH]
  • |Predictive Value of Tests[MESH]
  • |Retrospective Studies[MESH]
  • |Spinal Stenosis/surgery[MESH]


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