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10.1016/j.toxlet.2011.05.1034 http://scihub22266oqcxt.onion/10.1016/j.toxlet.2011.05.1034 21641981!ä!21641981 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Toxicol+Lett 2011 ; 205 (2): 146-53 Nephropedia Template TP {{tp|p=21641981|t=2011. Aflatoxins upregulate CYP3A4 mRNA expression in a process that involves the PXR transcription factor |pdf=|usr=}}{{21641981}} gab.com Text Aflatoxins upregulate CYP3A4 mRNA expression in a process that involves the PXR transcription factor JO: Toxicol Lett http://www.kidney.de/pget.php?&tw=1&pmid=21641981 #FOAvip Pregnane X receptor (PXR) is a member of the nuclear hormone receptor (NHR) superfamily, which regulates xenobiotic and endobiotic metabolism in the liver. This transcription factor is activated by structurally diverse ligands, including drugs and environmental pollutants. PXR regulates the expression of numerous genes that function in biotransformation and the disposition of xenobiotics upon binding to an AG(G/T)TCA DNA motif in target promoter regions. We performed a screen of mycotoxins that pose a known environmental threat to human and animal health for the ability to activate PXR function in a human hepatocyte cell line, HepG2. We found that aflatoxins B1, M1, and G1 activated PXR. This activation was associated with upregulation of CYP3A4 expression and increased occupancy of PXR protein on the CYP3A4 promoter. Using a microarray approach, we also found that aflatoxin B1 upregulated the expression of multiple genes involved in xenobiotic metabolism, including genes known to be regulated in a PXR-dependent fashion. We also observed an effect of aflatoxin B1 on the expression in other functional groups of genes, including the downregulation of genes involved in cholesterologenesis. The results of this study indicate that aflatoxin B1 is able to activate PXR, a known regulator of liver xenobiotic metabolism, in human hepatocytes, and it can upregulate the expression of PXR-dependent genes responsible for aflatoxin B1 biotransformation, including CYP3A4. Twit Text FOAVip Aflatoxins upregulate CYP3A4 mRNA expression in a process that involves the PXR transcription factor ????Toxicol Lett http://www.kidney.de/pget.php?&tw=1&pmid=21641981 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21641981 #FOAvip English Wikipedia <ref>{{Cite pmid|21641981}}</ref> Aflatoxins upregulate CYP3A4 mRNA expression in a process that involves the PXR transcription factor #MMPMID21641981 Ratajewski M; Walczak-Drzewiecka A; Salkowska A; Dastych J Toxicol Lett 2011[Aug]; 205 (2): 146-53 PMID21641981show ga Pregnane X receptor (PXR) is a member of the nuclear hormone receptor (NHR) superfamily, which regulates xenobiotic and endobiotic metabolism in the liver. This transcription factor is activated by structurally diverse ligands, including drugs and environmental pollutants. PXR regulates the expression of numerous genes that function in biotransformation and the disposition of xenobiotics upon binding to an AG(G/T)TCA DNA motif in target promoter regions. We performed a screen of mycotoxins that pose a known environmental threat to human and animal health for the ability to activate PXR function in a human hepatocyte cell line, HepG2. We found that aflatoxins B1, M1, and G1 activated PXR. This activation was associated with upregulation of CYP3A4 expression and increased occupancy of PXR protein on the CYP3A4 promoter. Using a microarray approach, we also found that aflatoxin B1 upregulated the expression of multiple genes involved in xenobiotic metabolism, including genes known to be regulated in a PXR-dependent fashion. We also observed an effect of aflatoxin B1 on the expression in other functional groups of genes, including the downregulation of genes involved in cholesterologenesis. The results of this study indicate that aflatoxin B1 is able to activate PXR, a known regulator of liver xenobiotic metabolism, in human hepatocytes, and it can upregulate the expression of PXR-dependent genes responsible for aflatoxin B1 biotransformation, including CYP3A4. |Aflatoxins/metabolism/pharmacokinetics/*toxicity[MESH] |Biotransformation[MESH] |Chromatin Immunoprecipitation[MESH] |Cytochrome P-450 CYP3A/*genetics[MESH] |Gene Expression Regulation, Enzymologic/*drug effects[MESH] |Hep G2 Cells[MESH] |Humans[MESH] |Luciferases/genetics[MESH] |Oligonucleotide Array Sequence Analysis[MESH] |Plasmids[MESH] |Pregnane X Receptor[MESH] |RNA, Messenger/*genetics[MESH] |Receptors, Steroid/*metabolism[MESH] |Reverse Transcriptase Polymerase Chain Reaction[MESH] |Transfection[MESH]Aflatoxins upregulate CYP3A4 mRNA expression in a process that involve(epmc).pdf DeepDyve Pubget Overpricing