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10.1002/ppul.21496 http://scihub22266oqcxt.onion/10.1002/ppul.21496 21626718!7167952!21626718     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21626718&cmd=llinks): Failed to open stream: HTTP request failed! 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Cytokine response in pediatric patients with pandemic influenza H1N1 2009 virus infection and pneumonia: comparison with pediatric pneumonia without H1N1 2009 infection |pdf=|usr=}}{{21626718}} gab.com Text Cytokine response in pediatric patients with pandemic influenza H1N1 2009 virus infection and pneumonia: comparison with pediatric pneumonia without H1N1 2009 infection JO: Pediatr Pulmonol http://www.kidney.de/pget.php?&tw=1&pmid=21626718 #FOAvip OBJECTIVES: We investigated serum cytokine levels in pediatric patients with pandemic influenza H1N1 2009 virus (H1N1) infection-pneumonia and in pediatric patients with pneumonia but without H1N1 infection, and examined correlations between cytokine levels and clinical/laboratory findings. METHODS: Fifty-seven cases of infection by H1N1 were confirmed by RT-PCR and enrolled. Of these 57 cases, 26 had a severe H1N1 infection (group 1), and 31 had a mild H1N1 infection (group 2). Sera from 18 cases with pneumonia without H1N1 infection (group 3) were used as controls. The serum levels of 10 cytokines were determined by multiplex assay. RESULTS: The serum levels of IFN-alpha, IL-6, and IP-10 were significantly higher in H1N1 infected cases than in group 3, and levels of IL-6 and IP-10 were significantly higher in group 1 than in group 2. The level of IL-10 was significantly higher in groups 1 and 3 than in group 2. However, levels of IFN-gamma and IL-17 were not significantly different between the three groups. IL-1beta, IL-4, and MIP-1alpha were not detectable in most patients. IP-10 and IL-6 levels were found to show negative correlations with lymphocyte count and oxygen saturation. CONCLUSIONS: We found higher levels of cytokines (IFN-alpha, IL-6, IP-10) of innate immunity than those of acquired immunity in pediatric H1N1 infection. Of the cytokines found to be increased in cases with H1N1 infection, IP-10 and IL-6 were found to be correlated with disease severity (lymphopenia and hypoxia). IP-10 and IL-6 may be important markers in pediatric H1N1 infection. Twit Text FOAVip Cytokine response in pediatric patients with pandemic influenza H1N1 2009 virus infection and pneumonia: comparison with pediatric pneumonia without H1N1 2009 infection ????Pediatr Pulmonol http://www.kidney.de/pget.php?&tw=1&pmid=21626718 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21626718 #FOAvip English Wikipedia <ref>{{Cite pmid|21626718}}</ref> Cytokine response in pediatric patients with pandemic influenza H1N1 2009 virus infection and pneumonia: comparison with pediatric pneumonia without H1N1 2009 infection #MMPMID21626718 Kim YH; Kim JE; Hyun MC Pediatr Pulmonol 2011[Dec]; 46 (12): 1233-9 PMID21626718show ga OBJECTIVES: We investigated serum cytokine levels in pediatric patients with pandemic influenza H1N1 2009 virus (H1N1) infection-pneumonia and in pediatric patients with pneumonia but without H1N1 infection, and examined correlations between cytokine levels and clinical/laboratory findings. METHODS: Fifty-seven cases of infection by H1N1 were confirmed by RT-PCR and enrolled. Of these 57 cases, 26 had a severe H1N1 infection (group 1), and 31 had a mild H1N1 infection (group 2). Sera from 18 cases with pneumonia without H1N1 infection (group 3) were used as controls. The serum levels of 10 cytokines were determined by multiplex assay. RESULTS: The serum levels of IFN-alpha, IL-6, and IP-10 were significantly higher in H1N1 infected cases than in group 3, and levels of IL-6 and IP-10 were significantly higher in group 1 than in group 2. The level of IL-10 was significantly higher in groups 1 and 3 than in group 2. However, levels of IFN-gamma and IL-17 were not significantly different between the three groups. IL-1beta, IL-4, and MIP-1alpha were not detectable in most patients. IP-10 and IL-6 levels were found to show negative correlations with lymphocyte count and oxygen saturation. CONCLUSIONS: We found higher levels of cytokines (IFN-alpha, IL-6, IP-10) of innate immunity than those of acquired immunity in pediatric H1N1 infection. Of the cytokines found to be increased in cases with H1N1 infection, IP-10 and IL-6 were found to be correlated with disease severity (lymphopenia and hypoxia). IP-10 and IL-6 may be important markers in pediatric H1N1 infection. |*Influenza A Virus, H1N1 Subtype[MESH] |*Pandemics[MESH] |Child[MESH] |Child, Preschool[MESH] |Cytokines/blood/*immunology[MESH] |Female[MESH] |Humans[MESH] |Influenza, Human/blood/*epidemiology/*immunology[MESH] |Lymphocyte Count[MESH] |Male[MESH] |Oxygen/blood[MESH] |Pneumonia/blood/*epidemiology/*immunology[MESH]Cytokine response in pediatric patients with pandemic influenza H1N1 2(epmc).pdf DeepDyve Pubget Overpricing