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10.1016/j.ad.2011.02.010 http://scihub22266oqcxt.onion/10.1016/j.ad.2011.02.010 21536246!ä!21536246 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21536246&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Actas+Dermosifiliogr 2011 ; 102 (6): 402-16 Nephropedia Template TP {{tp|p=21536246|t=2011. Rasopatias: trastornos del desarrollo con predisposicion al cancer y manifestaciones cutaneas |pdf=|usr=}}{{21536246}} gab.com Text Rasopatias: trastornos del desarrollo con predisposicion al cancer y manifestaciones cutaneas JO: Actas Dermosifiliogr http://www.kidney.de/pget.php?&tw=1&pmid=21536246 #FOAvip Proteins belonging to the RAS/mitogen activated protein kinase (MAPK) pathway play key roles in cell proliferation, differentiation, survival, and death. For more than 30 years now we have known that 30% of human cancers carry somatic mutations in genes encoding proteins from this pathway. Whereas somatic mutations have a high malignant potential, germline mutations are linked to developmental abnormalities that are often poorly clinically differentiated, although each is dependent upon the specific gene affected. Thus, all patients share varying degrees of mental retardation or learning difficulties, heart disease, facial dysmorphism, skin anomalies, and, in some cases, predisposition to cancer. These syndromes, known as rasopathies, include Noonan syndrome, Costello syndrome, neurofibromatosis-1, LEOPARD syndrome, cardiofaciocutaneous syndrome, and Legius syndrome. Recognizing the skin manifestations of rasopathies can facilitate diagnosis of these syndromes. Twit Text FOAVip Rasopatias: trastornos del desarrollo con predisposicion al cancer y manifestaciones cutaneas ????Actas Dermosifiliogr http://www.kidney.de/pget.php?&tw=1&pmid=21536246 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21536246 #FOAvip English Wikipedia <ref>{{Cite pmid|21536246}}</ref> Rasopatias: trastornos del desarrollo con predisposicion al cancer y manifestaciones cutaneas #MMPMID21536246 Hernandez-Martin A; Torrelo A Actas Dermosifiliogr 2011[Jul]; 102 (6): 402-16 PMID21536246show ga Proteins belonging to the RAS/mitogen activated protein kinase (MAPK) pathway play key roles in cell proliferation, differentiation, survival, and death. For more than 30 years now we have known that 30% of human cancers carry somatic mutations in genes encoding proteins from this pathway. Whereas somatic mutations have a high malignant potential, germline mutations are linked to developmental abnormalities that are often poorly clinically differentiated, although each is dependent upon the specific gene affected. Thus, all patients share varying degrees of mental retardation or learning difficulties, heart disease, facial dysmorphism, skin anomalies, and, in some cases, predisposition to cancer. These syndromes, known as rasopathies, include Noonan syndrome, Costello syndrome, neurofibromatosis-1, LEOPARD syndrome, cardiofaciocutaneous syndrome, and Legius syndrome. Recognizing the skin manifestations of rasopathies can facilitate diagnosis of these syndromes. |*Mutation[MESH] |Genetic Predisposition to Disease[MESH] |Humans[MESH] |MAP Kinase Signaling System/*genetics[MESH] |Neoplasms/*genetics[MESH] |Skin Diseases/*genetics[MESH] |Syndrome[MESH]Rasopatias: trastornos del desarrollo con predisposicion al cancer y (epmc).pdf DeepDyve Pubget Overpricing