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10.4161/org.7.2.15275 http://scihub22266oqcxt.onion/10.4161/org.7.2.15275 21519194!3142441!21519194     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Organogenesis 2011 ; 7 (2): 75-82 Nephropedia Template TP {{tp|p=21519194|t=2011. Organogenesis of the kidney glomerulus: focus on the glomerular basement membrane |pdf=|usr=}}{{21519194}} gab.com Text Organogenesis of the kidney glomerulus: focus on the glomerular basement membrane JO: Organogenesis http://www.kidney.de/pget.php?&tw=1&pmid=21519194 #FOAvip The glomerular basement membrane (GBM) is a crucial component of the kidney's filtration barrier that separates the vasculature from the urinary space. During glomerulogenesis, the GBM is formed from fusion of two distinct basement membranes, one synthesized by the glomerular epithelial cell (podocyte) and the other by the glomerular endothelial cell. The main components of the GBM are laminin-521 (alpha5beta2gamma1), collagen alpha3alpha4alpha5(IV), nidogen and the heparan sulfate proteoglycan, agrin. By studying mice lacking specific GBM components, we have shown that during glomerulogenesis, laminin is the only one that is required for GBM integrity and in turn, the GBM is required for completion of glomerulogenesis and glomerular vascularization. In addition, our results from laminin beta2-null mice suggest that laminin-521, and thus the GBM, contribute to the establishment and maintenance of the glomerular filtration barrier to plasma albumin. In contrast, mutations that affect GBM collagen IV or agrin do not impair glomerular development or cause immediate leakage of plasma proteins. However, collagen IV mutation, which causes Alport syndrome and ESRD in humans, leads to gradual damage to the GBM that eventually leads to albuminuria and renal failure. These results highlight the importance of the GBM for establishing and maintaining a perfectly functioning, highly selective glomerular filter. Twit Text FOAVip Organogenesis of the kidney glomerulus: focus on the glomerular basement membrane ????Organogenesis http://www.kidney.de/pget.php?&tw=1&pmid=21519194 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21519194 #FOAvip English Wikipedia <ref>{{Cite pmid|21519194}}</ref> Organogenesis of the kidney glomerulus: focus on the glomerular basement membrane #MMPMID21519194 Miner JH Organogenesis 2011[Apr]; 7 (2): 75-82 PMID21519194show ga The glomerular basement membrane (GBM) is a crucial component of the kidney's filtration barrier that separates the vasculature from the urinary space. During glomerulogenesis, the GBM is formed from fusion of two distinct basement membranes, one synthesized by the glomerular epithelial cell (podocyte) and the other by the glomerular endothelial cell. The main components of the GBM are laminin-521 (alpha5beta2gamma1), collagen alpha3alpha4alpha5(IV), nidogen and the heparan sulfate proteoglycan, agrin. By studying mice lacking specific GBM components, we have shown that during glomerulogenesis, laminin is the only one that is required for GBM integrity and in turn, the GBM is required for completion of glomerulogenesis and glomerular vascularization. In addition, our results from laminin beta2-null mice suggest that laminin-521, and thus the GBM, contribute to the establishment and maintenance of the glomerular filtration barrier to plasma albumin. In contrast, mutations that affect GBM collagen IV or agrin do not impair glomerular development or cause immediate leakage of plasma proteins. However, collagen IV mutation, which causes Alport syndrome and ESRD in humans, leads to gradual damage to the GBM that eventually leads to albuminuria and renal failure. These results highlight the importance of the GBM for establishing and maintaining a perfectly functioning, highly selective glomerular filter. |*Organogenesis[MESH] |Animals[MESH] |Glomerular Basement Membrane/*metabolism/ultrastructure[MESH] |Heparan Sulfate Proteoglycans/metabolism[MESH] |Humans[MESH] |Kidney Glomerulus/cytology/*embryology/metabolism[MESH] |Laminin/metabolism[MESH]Organogenesis of the kidney glomerulus: focus on the glomerular baseme(epmc).pdf DeepDyve Pubget Overpricing