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10.1016/j.diabres.2011.03.019 http://scihub22266oqcxt.onion/10.1016/j.diabres.2011.03.019 21514683!ä!21514683 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diabetes+Res+Clin+Pract 2011 ; 93 (1): 63-9 Nephropedia Template TP {{tp|p=21514683|t=2011. Effect of pioglitazone on diabetic nephropathy and expression of HIF-1alpha and VEGF in the renal tissues of type 2 diabetic rats |pdf=|usr=}}{{21514683}} gab.com Text Effect of pioglitazone on diabetic nephropathy and expression of HIF-1alpha and VEGF in the renal tissues of type 2 diabetic rats JO: Diabetes Res Clin Pract http://www.kidney.de/pget.php?&tw=1&pmid=21514683 #FOAvip OBJECTIVE: To investigate the effect of pioglitazone on the progression of diabetic nephropathy and the expression of hypoxia inducible factor-1alpha (HIF-1a) and vascular endothelial growth factor (VEGF) in a rat model of type-2 diabetes. METHODS: Streptozotocin-induced type-2 diabetes mellitus (DM) model was set up in male Sprague Dawley rats. DM rats were treated with or without pioglitazone (4 mg/kg/day for 8 weeks) and/or cobalt chloride. Normal rats were used as controls. The blood chemistry, urine albumin, kidney histology, and expression of HIF-1alpha and VEGF of the different groups were compared. RESULTS: The kidney weights and kidney weight indexes of DM rats were significantly higher than in NC rats (P<0.01) and the kidney weights and kidney weight indexes of rats in pioglitazone and/or cobalt chloride treatment group were significantly less than in DM group. Relative to rats in the NC group, rats in the DM group had significantly disrupted serum chemistry, urinary albumin, and kidney histology, and significantly enhanced expression of HIF-1a and VEGF. Rats in the pioglitazone and/or cobalt chloride treatment group experienced significant amelioration of these effects. CONCLUSION: In a rat model, pioglitazone ameliorated many of the physiological, cellular, and molecular processes associated with diabetic nephropathy. Twit Text FOAVip Effect of pioglitazone on diabetic nephropathy and expression of HIF-1alpha and VEGF in the renal tissues of type 2 diabetic rats ????Diabetes Res Clin Pract http://www.kidney.de/pget.php?&tw=1&pmid=21514683 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21514683 #FOAvip English Wikipedia <ref>{{Cite pmid|21514683}}</ref> Effect of pioglitazone on diabetic nephropathy and expression of HIF-1alpha and VEGF in the renal tissues of type 2 diabetic rats #MMPMID21514683 Xu X; Chen P; Zheng Q; Wang Y; Chen W Diabetes Res Clin Pract 2011[Jul]; 93 (1): 63-9 PMID21514683show ga OBJECTIVE: To investigate the effect of pioglitazone on the progression of diabetic nephropathy and the expression of hypoxia inducible factor-1alpha (HIF-1a) and vascular endothelial growth factor (VEGF) in a rat model of type-2 diabetes. METHODS: Streptozotocin-induced type-2 diabetes mellitus (DM) model was set up in male Sprague Dawley rats. DM rats were treated with or without pioglitazone (4 mg/kg/day for 8 weeks) and/or cobalt chloride. Normal rats were used as controls. The blood chemistry, urine albumin, kidney histology, and expression of HIF-1alpha and VEGF of the different groups were compared. RESULTS: The kidney weights and kidney weight indexes of DM rats were significantly higher than in NC rats (P<0.01) and the kidney weights and kidney weight indexes of rats in pioglitazone and/or cobalt chloride treatment group were significantly less than in DM group. Relative to rats in the NC group, rats in the DM group had significantly disrupted serum chemistry, urinary albumin, and kidney histology, and significantly enhanced expression of HIF-1a and VEGF. Rats in the pioglitazone and/or cobalt chloride treatment group experienced significant amelioration of these effects. CONCLUSION: In a rat model, pioglitazone ameliorated many of the physiological, cellular, and molecular processes associated with diabetic nephropathy. |Animals[MESH] |Blotting, Western[MESH] |Body Weight/drug effects[MESH] |Diabetes Mellitus, Type 2/*drug therapy/*metabolism[MESH] |Diabetic Nephropathies/drug therapy/*metabolism[MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism[MESH] |Immunohistochemistry[MESH] |Kidney/drug effects/*metabolism[MESH] |Male[MESH] |Organ Size/drug effects[MESH] |Pioglitazone[MESH] |Rats[MESH] |Rats, Sprague-Dawley[MESH] |Thiazolidinediones/*therapeutic use[MESH]Effect of pioglitazone on diabetic nephropathy and expression of HIF-1(epmc).pdf DeepDyve Pubget Overpricing