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10.1007/s00467-011-1871-4 http://scihub22266oqcxt.onion/10.1007/s00467-011-1871-4 21503667!3163795!21503667     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pediatr+Nephrol 2011 ; 26 (10): 1789-802 Nephropedia Template TP {{tp|p=21503667|t=2011. Bartter- and Gitelman-like syndromes: salt-losing tubulopathies with loop or DCT defects |pdf=|usr=}}{{21503667}} gab.com Text Bartter- and Gitelman-like syndromes: salt-losing tubulopathies with loop or DCT defects JO: Pediatr Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=21503667 #FOAvip Salt-losing tubulopathies with secondary hyperaldosteronism (SLT) comprise a set of well-defined inherited tubular disorders. Two segments along the distal nephron are primarily involved in the pathogenesis of SLTs: the thick ascending limb of Henle's loop, and the distal convoluted tubule (DCT). The functions of these pre- and postmacula densa segments are quite distinct, and this has a major impact on the clinical presentation of loop and DCT disorders - the Bartter- and Gitelman-like syndromes. Defects in the water-impermeable thick ascending limb, with its greater salt reabsorption capacity, lead to major salt and water losses similar to the effect of loop diuretics. In contrast, defects in the DCT, with its minor capacity of salt reabsorption and its crucial role in fine-tuning of urinary calcium and magnesium excretion, provoke more chronic solute imbalances similar to the effects of chronic treatment with thiazides. The most severe disorder is a combination of a loop and DCT disorder similar to the enhanced diuretic effect of a co-medication of loop diuretics with thiazides. Besides salt and water supplementation, prostaglandin E2-synthase inhibition is the most effective therapeutic option in polyuric loop disorders (e.g., pure furosemide and mixed furosemide-amiloride type), especially in preterm infants with severe volume depletion. In DCT disorders (e.g., pure thiazide and mixed thiazide-furosemide type), renin-angiotensin-aldosterone system (RAAS) blockers might be indicated after salt, potassium, and magnesium supplementation are deemed insufficient. It appears that in most patients with SLT, a combination of solute supplementation with some drug treatment (e.g., indomethacin) is needed for a lifetime. Twit Text FOAVip Bartter- and Gitelman-like syndromes: salt-losing tubulopathies with loop or DCT defects ????Pediatr Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=21503667 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21503667 #FOAvip English Wikipedia <ref>{{Cite pmid|21503667}}</ref> Bartter- and Gitelman-like syndromes: salt-losing tubulopathies with loop or DCT defects #MMPMID21503667 Seyberth HW; Schlingmann KP Pediatr Nephrol 2011[Oct]; 26 (10): 1789-802 PMID21503667show ga Salt-losing tubulopathies with secondary hyperaldosteronism (SLT) comprise a set of well-defined inherited tubular disorders. Two segments along the distal nephron are primarily involved in the pathogenesis of SLTs: the thick ascending limb of Henle's loop, and the distal convoluted tubule (DCT). The functions of these pre- and postmacula densa segments are quite distinct, and this has a major impact on the clinical presentation of loop and DCT disorders - the Bartter- and Gitelman-like syndromes. Defects in the water-impermeable thick ascending limb, with its greater salt reabsorption capacity, lead to major salt and water losses similar to the effect of loop diuretics. In contrast, defects in the DCT, with its minor capacity of salt reabsorption and its crucial role in fine-tuning of urinary calcium and magnesium excretion, provoke more chronic solute imbalances similar to the effects of chronic treatment with thiazides. The most severe disorder is a combination of a loop and DCT disorder similar to the enhanced diuretic effect of a co-medication of loop diuretics with thiazides. Besides salt and water supplementation, prostaglandin E2-synthase inhibition is the most effective therapeutic option in polyuric loop disorders (e.g., pure furosemide and mixed furosemide-amiloride type), especially in preterm infants with severe volume depletion. In DCT disorders (e.g., pure thiazide and mixed thiazide-furosemide type), renin-angiotensin-aldosterone system (RAAS) blockers might be indicated after salt, potassium, and magnesium supplementation are deemed insufficient. It appears that in most patients with SLT, a combination of solute supplementation with some drug treatment (e.g., indomethacin) is needed for a lifetime. |Adult[MESH] |Aldosterone/pharmacology/physiology[MESH] |Bartter Syndrome/diagnosis/*pathology/therapy[MESH] |Female[MESH] |Gitelman Syndrome/diagnosis/*pathology/therapy[MESH] |Humans[MESH] |Hyperaldosteronism/complications/pathology[MESH] |Kidney Diseases/diagnosis/*pathology/therapy[MESH] |Kidney Tubules, Distal/pathology[MESH] |Kidney Tubules/*pathology[MESH] |Loop of Henle/metabolism/pathology[MESH] |Nephrons/pathology[MESH] |Prognosis[MESH]Bartter- and Gitelman-like syndromes: salt-losing tubulopathies with l(epmc).pdf DeepDyve Pubget Overpricing