Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.1007/s00467-011-1858-1

http://scihub22266oqcxt.onion/10.1007/s00467-011-1858-1
suck pdf from google scholar
21499773!ä!21499773

suck abstract from ncbi

pmid21499773      Pediatr+Nephrol 2011 ; 26 (9): 1535-43
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • Wilms tumor--a renal stem cell malignancy? #MMPMID21499773
  • Pode-Shakked N; Dekel B
  • Pediatr Nephrol 2011[Sep]; 26 (9): 1535-43 PMID21499773show ga
  • Wilms' tumor (WT; nephroblastoma) is the most common pediatric renal malignancy and rated fourth in overall incidence among childhood cancers. It is viewed as a prototype of differentiation failure in human neoplasia as it recapitulates the histology of the nephrogenic zone of the growing fetal kidney. The cellular origin of WT is unclear. However, recent genomic, genetic and epigenetic studies point to an early renal stem/progenitor cell that undergoes malignant transformation as the source for WT. In this context, classical WT shares genes and pathways activated in progenitors committed to the renal lineage. However, direct proof and characterization of the WT initiating cell have remained elusive. Novel methodologies recently adopted from the cancer stem cell scientific field, including the analysis of sorted single human tumor cells, have been applied to WT. These have enabled the identification of cell sub-populations that show similarities-in terms of molecular marker expression-to human fetal kidney progenitors and are, therefore, likely to be derivatives of the same lineage. Further elucidation of the WT cancer stem cell or the cell of origin in human tumors and in transgenic mouse models that generate murine tumors may not only provide novel therapeutic targets but also shed light on the normal kidney stem cell.
  • |Animals[MESH]
  • |Cell Lineage[MESH]
  • |Epigenesis, Genetic[MESH]
  • |Gene Expression Profiling/methods[MESH]
  • |Gene Expression Regulation, Developmental[MESH]
  • |Gene Expression Regulation, Neoplastic[MESH]
  • |Humans[MESH]
  • |Kidney Neoplasms/genetics/metabolism/*pathology[MESH]
  • |Neoplastic Stem Cells/metabolism/*pathology[MESH]
  • |Oligonucleotide Array Sequence Analysis[MESH]
  • |Signal Transduction[MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    Linkout box