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10.1016/j.molimm.2011.03.010 http://scihub22266oqcxt.onion/10.1016/j.molimm.2011.03.010 21481937!ä!21481937 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Immunol 2011 ; 48 (9-10): 1253-62 Nephropedia Template TP {{tp|p=21481937|t=2011. Involvement of NF-kappaB in changes of IFN-gamma-induced CIITA/MHC-II and iNOS expression by influenza virus in macrophages |pdf=|usr=}}{{21481937}} gab.com Text Involvement of NF-kappaB in changes of IFN-gamma-induced CIITA/MHC-II and iNOS expression by influenza virus in macrophages JO: Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=21481937 #FOAvip Type II interferon (IFN-gamma) plays an important role in defense against viral infection. Although this cytokine is found during influenza virus infection, it seems to have no protective function against the virus, and the reasons for this are not clear. To determine how the influenza virus overcomes the antiviral effects of IFN-gamma, we examined the effect of A/Puerto-Rico/8/34 (H1N1) (PR8) infection on the expression of various IFN-gamma inducible genes involved in defense against virus infection. The results showed that PR8 selectively affects IFN-gamma induced MHC-II and iNOS expression in both the murine macrophage-like cell line, Raw264.7, and in primary alveolar macrophages. Infection of IFN-gamma treated macrophages with PR8 resulted in decreased expression of CIITA/MHC-II and increased production of iNOS/NO. These changes correlate with activation of NF-kappaB but not with JAK/STAT signaling. The data indicate one possible mechanism underlying the ineffectiveness of IFN-gamma against influenza virus, and suggest that NF-kappaB may be a promising target for anti-influenza drugs. Twit Text FOAVip Involvement of NF-kappaB in changes of IFN-gamma-induced CIITA/MHC-II and iNOS expression by influenza virus in macrophages ????Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=21481937 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21481937 #FOAvip English Wikipedia <ref>{{Cite pmid|21481937}}</ref> Involvement of NF-kappaB in changes of IFN-gamma-induced CIITA/MHC-II and iNOS expression by influenza virus in macrophages #MMPMID21481937 Hang do TT; Song JY; Kim MY; Park JW; Shin YK Mol Immunol 2011[May]; 48 (9-10): 1253-62 PMID21481937show ga Type II interferon (IFN-gamma) plays an important role in defense against viral infection. Although this cytokine is found during influenza virus infection, it seems to have no protective function against the virus, and the reasons for this are not clear. To determine how the influenza virus overcomes the antiviral effects of IFN-gamma, we examined the effect of A/Puerto-Rico/8/34 (H1N1) (PR8) infection on the expression of various IFN-gamma inducible genes involved in defense against virus infection. The results showed that PR8 selectively affects IFN-gamma induced MHC-II and iNOS expression in both the murine macrophage-like cell line, Raw264.7, and in primary alveolar macrophages. Infection of IFN-gamma treated macrophages with PR8 resulted in decreased expression of CIITA/MHC-II and increased production of iNOS/NO. These changes correlate with activation of NF-kappaB but not with JAK/STAT signaling. The data indicate one possible mechanism underlying the ineffectiveness of IFN-gamma against influenza virus, and suggest that NF-kappaB may be a promising target for anti-influenza drugs. |Animals[MESH] |Cell Line[MESH] |Gene Expression Regulation/drug effects[MESH] |Histocompatibility Antigens Class II/genetics/*metabolism[MESH] |Interferon-gamma/*pharmacology[MESH] |Janus Kinases/metabolism[MESH] |Macrophage Activation/drug effects[MESH] |Macrophages/drug effects/*enzymology/virology[MESH] |Mice[MESH] |NF-kappa B/*metabolism[MESH] |Nitric Oxide Synthase Type II/*metabolism[MESH] |Nitric Oxide/metabolism[MESH] |Nuclear Proteins/*metabolism[MESH] |Orthomyxoviridae Infections/immunology/virology[MESH] |Orthomyxoviridae/drug effects/*physiology[MESH] |STAT1 Transcription Factor/metabolism[MESH] |Signal Transduction/drug effects[MESH]Involvement of NF-kappaB in changes of IFN-gamma-induced CIITA/MHC-II (epmc).pdf DeepDyve Pubget Overpricing