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10.1159/000327958 http://scihub22266oqcxt.onion/10.1159/000327958 21471721!ä!21471721 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Physiol+Biochem 2011 ; 27 (3-4): 313-26 Nephropedia Template TP {{tp|p=21471721|t=2011. Alteration of the transcriptional profile of human embryonic kidney cells by transient overexpression of mouse TRPM7 channels |pdf=|usr=}}{{21471721}} gab.com Text Alteration of the transcriptional profile of human embryonic kidney cells by transient overexpression of mouse TRPM7 channels JO: Cell Physiol Biochem http://www.kidney.de/pget.php?&tw=1&pmid=21471721 #FOAvip BACKGROUND: TRPM7 is a cation channel containing a functional kinase domain. The functional activity of TRPM7 is essential for cell viability and growth, and its expression is up-regulated in certain pathological conditions, such as ischemia. METHODS: In order to assess the effects of TRPM7 activity on cellular gene expression, inducible HEK293 cell-lines harboring the wild-type mouse TRPM7 and a mutant lacking the kinase domain were established. The wild-type and the non-functional TRPM7 channels were induced transiently and the comparative changes in cellular transcription were investigated. RESULTS: From the genome-scale analysis using a human genome expression microarray, we identified 951 genes altered in transcription significantly and specifically by the expression of the functional TRPM7 channel. CONCLUSION: By analyzing the genes differentially expressed by TRPM7, we were able to provide potential target proteins and to delineate the cellular pathways affected by the channel function. Twit Text FOAVip Alteration of the transcriptional profile of human embryonic kidney cells by transient overexpression of mouse TRPM7 channels ????Cell Physiol Biochem http://www.kidney.de/pget.php?&tw=1&pmid=21471721 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21471721 #FOAvip English Wikipedia <ref>{{Cite pmid|21471721}}</ref> Alteration of the transcriptional profile of human embryonic kidney cells by transient overexpression of mouse TRPM7 channels #MMPMID21471721 Lee BC; Hong SE; Lim HH; Kim DH; Park CS Cell Physiol Biochem 2011[]; 27 (3-4): 313-26 PMID21471721show ga BACKGROUND: TRPM7 is a cation channel containing a functional kinase domain. The functional activity of TRPM7 is essential for cell viability and growth, and its expression is up-regulated in certain pathological conditions, such as ischemia. METHODS: In order to assess the effects of TRPM7 activity on cellular gene expression, inducible HEK293 cell-lines harboring the wild-type mouse TRPM7 and a mutant lacking the kinase domain were established. The wild-type and the non-functional TRPM7 channels were induced transiently and the comparative changes in cellular transcription were investigated. RESULTS: From the genome-scale analysis using a human genome expression microarray, we identified 951 genes altered in transcription significantly and specifically by the expression of the functional TRPM7 channel. CONCLUSION: By analyzing the genes differentially expressed by TRPM7, we were able to provide potential target proteins and to delineate the cellular pathways affected by the channel function. |*Gene Expression Profiling[MESH] |Animals[MESH] |Genome, Human[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Mice[MESH] |Microarray Analysis[MESH] |TRPM Cation Channels/genetics/*metabolism[MESH]Alteration of the transcriptional profile of human embryonic kidney ce(epmc).pdf DeepDyve Pubget Overpricing