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10.1089/vim.2010.0118 http://scihub22266oqcxt.onion/10.1089/vim.2010.0118 21449718!ä!21449718 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viral+Immunol 2011 ; 24 (2): 77-88 Nephropedia Template TP {{tp|p=21449718|t=2011. Responses of mouse airway epithelial cells and alveolar macrophages to virulent and avirulent strains of influenza A virus |pdf=|usr=}}{{21449718}} gab.com Text Responses of mouse airway epithelial cells and alveolar macrophages to virulent and avirulent strains of influenza A virus JO: Viral Immunol http://www.kidney.de/pget.php?&tw=1&pmid=21449718 #FOAvip Influenza A virus (IAV) infection is associated with outcomes ranging from subclinical infection to severe pneumonia. In this study, we compared IAV strains BJx109 (H3N2), HKx31 (H3N2), and PR8 (H1N1), for their ability to elicit innate immune responses from mouse airway cells in vitro and their virulence in mice. The viruses differed markedly in their ability to induce disease in mice (PR8 > HKx31 > BJx109). In particular, PR8 infection was associated with high levels of virus replication and pulmonary inflammation. We next compared the ability of each virus strain to infect and induce inflammatory mediators from mouse airway cells. First, major differences were observed in the ability of viruses to infect and induce chemokines and cytokines from mouse alveolar macrophages (BJx109 > HKx31 > PR8), but not from airway epithelial cells (AEC) in vitro. Second, C-type lectins of the innate immune system in mouse lung fluids blocked the ability of BJx109, but not PR8, to infect mouse macrophages and AEC. The failure of the virulent PR8 virus to elicit responses from airway macrophages, combined with resistance to antiviral proteins in mouse airway fluids, likely contribute to virulence in mice. These findings provide insight into the mechanisms underlying disease severity in the mouse model of influenza infection. Twit Text FOAVip Responses of mouse airway epithelial cells and alveolar macrophages to virulent and avirulent strains of influenza A virus ????Viral Immunol http://www.kidney.de/pget.php?&tw=1&pmid=21449718 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21449718 #FOAvip English Wikipedia <ref>{{Cite pmid|21449718}}</ref> Responses of mouse airway epithelial cells and alveolar macrophages to virulent and avirulent strains of influenza A virus #MMPMID21449718 Tate MD; Schilter HC; Brooks AG; Reading PC Viral Immunol 2011[Apr]; 24 (2): 77-88 PMID21449718show ga Influenza A virus (IAV) infection is associated with outcomes ranging from subclinical infection to severe pneumonia. In this study, we compared IAV strains BJx109 (H3N2), HKx31 (H3N2), and PR8 (H1N1), for their ability to elicit innate immune responses from mouse airway cells in vitro and their virulence in mice. The viruses differed markedly in their ability to induce disease in mice (PR8 > HKx31 > BJx109). In particular, PR8 infection was associated with high levels of virus replication and pulmonary inflammation. We next compared the ability of each virus strain to infect and induce inflammatory mediators from mouse airway cells. First, major differences were observed in the ability of viruses to infect and induce chemokines and cytokines from mouse alveolar macrophages (BJx109 > HKx31 > PR8), but not from airway epithelial cells (AEC) in vitro. Second, C-type lectins of the innate immune system in mouse lung fluids blocked the ability of BJx109, but not PR8, to infect mouse macrophages and AEC. The failure of the virulent PR8 virus to elicit responses from airway macrophages, combined with resistance to antiviral proteins in mouse airway fluids, likely contribute to virulence in mice. These findings provide insight into the mechanisms underlying disease severity in the mouse model of influenza infection. |Animals[MESH] |Antiviral Agents/metabolism[MESH] |Cytokines/metabolism[MESH] |Epithelial Cells/*virology[MESH] |Influenza A Virus, H1N1 Subtype/*immunology/*pathogenicity[MESH] |Influenza A Virus, H3N2 Subtype/*immunology/*pathogenicity[MESH] |Lectins/metabolism[MESH] |Lung/pathology/virology[MESH] |Macrophages, Alveolar/*virology[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Orthomyxoviridae Infections/pathology/virology[MESH]Responses of mouse airway epithelial cells and alveolar macrophages to(epmc).pdf DeepDyve Pubget Overpricing