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10.1038/nrneph.2011.26 http://scihub22266oqcxt.onion/10.1038/nrneph.2011.26 21423249!ä!21423249 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Nephrol 2011 ; 7 (5): 286-94 Nephropedia Template TP {{tp|p=21423249|t=2011. MicroRNAs as mediators and therapeutic targets in chronic kidney disease |pdf=|usr=}}{{21423249}} gab.com Text MicroRNAs as mediators and therapeutic targets in chronic kidney disease JO: Nat Rev Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=21423249 #FOAvip Chronic kidney disease (CKD) is characterized by tubulointerstitial deposition of extracellular matrix, tubular atrophy and dilatation; the replacement of organ architecture by connective tissue results in progressive loss of organ function. Micro (mi)RNAs are important mediators of tissue fibrosis under various pathological conditions and are of potential therapeutic relevance. These short, noncoding nucleotides ( approximately 22 bases) regulate target messenger RNAs at the post-transcriptional level. Several hundred miRNAs regulate a considerable amount of the human genome and are involved in virtually all biological processes, including cellular proliferation, apoptosis and differentiation. Thus, miRNA deregulation often results in impaired cellular function and development of disease. Here, we summarize the current knowledge on the role of miRNAs in CKD, with particular emphasis on hypertensive kidney disease, diabetic nephropathy, glomerular biology, and IgA nephropathy. Identification of miRNA regulation and function in renal pathology may pinpoint miRNAs as new therapeutic targets in kidney fibrosis and related diseases. A new class of RNA therapeutics, that is, miRNA modulators (such as antagomirs) have been developed, which enable specific targeting of miRNAs and respective downstream gene networks in vivo, thus influencing the mechanisms that underlie disease initiation or progression. The therapeutic potential of miRNA-based treatment strategies in CKD are discussed. Twit Text FOAVip MicroRNAs as mediators and therapeutic targets in chronic kidney disease ????Nat Rev Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=21423249 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21423249 #FOAvip English Wikipedia <ref>{{Cite pmid|21423249}}</ref> MicroRNAs as mediators and therapeutic targets in chronic kidney disease #MMPMID21423249 Lorenzen JM; Haller H; Thum T Nat Rev Nephrol 2011[May]; 7 (5): 286-94 PMID21423249show ga Chronic kidney disease (CKD) is characterized by tubulointerstitial deposition of extracellular matrix, tubular atrophy and dilatation; the replacement of organ architecture by connective tissue results in progressive loss of organ function. Micro (mi)RNAs are important mediators of tissue fibrosis under various pathological conditions and are of potential therapeutic relevance. These short, noncoding nucleotides ( approximately 22 bases) regulate target messenger RNAs at the post-transcriptional level. Several hundred miRNAs regulate a considerable amount of the human genome and are involved in virtually all biological processes, including cellular proliferation, apoptosis and differentiation. Thus, miRNA deregulation often results in impaired cellular function and development of disease. Here, we summarize the current knowledge on the role of miRNAs in CKD, with particular emphasis on hypertensive kidney disease, diabetic nephropathy, glomerular biology, and IgA nephropathy. Identification of miRNA regulation and function in renal pathology may pinpoint miRNAs as new therapeutic targets in kidney fibrosis and related diseases. A new class of RNA therapeutics, that is, miRNA modulators (such as antagomirs) have been developed, which enable specific targeting of miRNAs and respective downstream gene networks in vivo, thus influencing the mechanisms that underlie disease initiation or progression. The therapeutic potential of miRNA-based treatment strategies in CKD are discussed. |*Genetic Therapy[MESH] |Animals[MESH] |Fibrosis[MESH] |Humans[MESH] |Kidney Failure, Chronic/*genetics/pathology/*therapy[MESH] |MicroRNAs/*genetics[MESH]MicroRNAs as mediators and therapeutic targets in chronic kidney disea(epmc).pdf DeepDyve Pubget Overpricing