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10.1097/SHK.0b013e318219ff2a http://scihub22266oqcxt.onion/10.1097/SHK.0b013e318219ff2a 21412184!ä!21412184 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Shock 2011 ; 36 (1): 90-6 Nephropedia Template TP {{tp|p=21412184|t=2011. Hypoxia-inducible factor 1alpha regulates the expression of the mitochondrial ATPase inhibitor protein (IF1) in rat liver |pdf=|usr=}}{{21412184}} gab.com Text Hypoxia-inducible factor 1alpha regulates the expression of the mitochondrial ATPase inhibitor protein (IF1) in rat liver JO: Shock http://www.kidney.de/pget.php?&tw=1&pmid=21412184 #FOAvip A growing number of reports indicate that bioenergetic failure plays a crucial role in the development of multiple organ failure during sepsis. Our previous results showed that the suppression of IF1 (mitochondrial ATPase inhibitor protein) expression and subsequent elevated mitochondrial F(o)F(1)-ATPase activity might contribute to the bioenergetic failure in the liver during sepsis, and the influence of the decreased transcriptional level of IF1 might be an important factor. In this study, we investigated the interaction of IF1 protein expression and hypoxia-inducible factor 1 (HIF-1), a transcription factor that is correlated with the inflammatory status in sepsis. The results showed that nuclear HIF-1alpha protein, a subunit of HIF-1, and IF1 mRNA expression were coincidently reduced in late septic liver of rats. Furthermore, in vitro, overexpression of HIF-1alpha by hypoxia or CoCl(2) (HIF-1alpha activator) treatment augmented IF1 protein levels. On the contrary, HIF-1alpha antisense oligonucleotide and siRNA were used to specifically downregulate HIF-1alpha expression, and then IF1 protein levels were significantly decreased in clone 9 cells. Meanwhile, downregulation of HIF-1alpha expression led to elevate the mitochondrial F(o)F(1)-ATPase activity in the presence of Bis-Tris buffer (pH 6.5). In conclusion, these results suggested for the first time that the HIF-1 might play a crucial role in regulating IF1 protein expression in late septic liver. Twit Text FOAVip Hypoxia-inducible factor 1alpha regulates the expression of the mitochondrial ATPase inhibitor protein (IF1) in rat liver ????Shock http://www.kidney.de/pget.php?&tw=1&pmid=21412184 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21412184 #FOAvip English Wikipedia <ref>{{Cite pmid|21412184}}</ref> Hypoxia-inducible factor 1alpha regulates the expression of the mitochondrial ATPase inhibitor protein (IF1) in rat liver #MMPMID21412184 Huang LJ; Chuang IC; Dong HP; Yang RC Shock 2011[Jul]; 36 (1): 90-6 PMID21412184show ga A growing number of reports indicate that bioenergetic failure plays a crucial role in the development of multiple organ failure during sepsis. Our previous results showed that the suppression of IF1 (mitochondrial ATPase inhibitor protein) expression and subsequent elevated mitochondrial F(o)F(1)-ATPase activity might contribute to the bioenergetic failure in the liver during sepsis, and the influence of the decreased transcriptional level of IF1 might be an important factor. In this study, we investigated the interaction of IF1 protein expression and hypoxia-inducible factor 1 (HIF-1), a transcription factor that is correlated with the inflammatory status in sepsis. The results showed that nuclear HIF-1alpha protein, a subunit of HIF-1, and IF1 mRNA expression were coincidently reduced in late septic liver of rats. Furthermore, in vitro, overexpression of HIF-1alpha by hypoxia or CoCl(2) (HIF-1alpha activator) treatment augmented IF1 protein levels. On the contrary, HIF-1alpha antisense oligonucleotide and siRNA were used to specifically downregulate HIF-1alpha expression, and then IF1 protein levels were significantly decreased in clone 9 cells. Meanwhile, downregulation of HIF-1alpha expression led to elevate the mitochondrial F(o)F(1)-ATPase activity in the presence of Bis-Tris buffer (pH 6.5). In conclusion, these results suggested for the first time that the HIF-1 might play a crucial role in regulating IF1 protein expression in late septic liver. |ATPase Inhibitory Protein[MESH] |Animals[MESH] |Blotting, Western[MESH] |Cell Line[MESH] |Cells, Cultured[MESH] |Cobalt/pharmacology[MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/antagonists & inhibitors/genetics/*metabolism[MESH] |Liver/*enzymology/*metabolism[MESH] |Male[MESH] |Mitochondrial Proteins[MESH] |Oligonucleotides, Antisense/pharmacology[MESH] |Proteins/*metabolism[MESH] |RNA, Small Interfering[MESH] |Rats[MESH] |Rats, Sprague-Dawley[MESH] |Reverse Transcriptase Polymerase Chain Reaction[MESH]Hypoxia-inducible factor 1alpha regulates the expression of the mitoch(epmc).pdf DeepDyve Pubget Overpricing