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Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Gen+Virol 2011 ; 92 (Pt 7): 1662-1665 Nephropedia Template TP
gab.com Text
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English Wikipedia
Long-term impairment of Streptococcus pneumoniae lung clearance is observed after initial infection with influenza A virus but not human metapneumovirus in mice #MMPMID21411678
Ludewick HP; Aerts L; Hamelin ME; Boivin G
J Gen Virol 2011[Jul]; 92 (Pt 7): 1662-1665 PMID21411678show ga
Human metapneumovirus (hMPV) is a paramyxovirus responsible for respiratory tract infections in humans. Our objective was to investigate whether hMPV could predispose to long-term bacterial susceptibility, such as previously observed with influenza viruses. BALB/c mice were infected with hMPV or influenza A and, 14 days following viral infection, challenged with Streptococcus pneumoniae. Only mice previously infected with influenza A demonstrated an 8% weight loss of their body weight 72 h following S. pneumoniae infection, which correlated with an enhanced lung bacterial replication of >7 log(10) compared with pneumococcus infection alone. This enhanced bacterial replication was not related to altered macrophage or neutrophil recruitment or deficient production of critical cytokines. However, bacterial challenge induced the production of gamma interferon in bronchoalveolar lavages of influenza-infected mice, but not in those of hMPV-infected animals. In conclusion, hMPV does not cause long-term impairment of pneumococcus lung clearance, in contrast to influenza A virus.
|Animals[MESH]
|Cytokines/immunology[MESH]
|Disease Models, Animal[MESH]
|Disease Susceptibility[MESH]
|Humans[MESH]
|Influenza A Virus, H1N1 Subtype/immunology/*physiology[MESH]