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10.1089/jir.2010.0143 http://scihub22266oqcxt.onion/10.1089/jir.2010.0143 21352081!ä!21352081 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Interferon+Cytokine+Res 2011 ; 31 (6): 501-8 Nephropedia Template TP {{tp|p=21352081|t=2011. Susceptibility to infection and inflammatory response following influenza virus (H1N1, A/PR/8/34) challenge: role of macrophages |pdf=|usr=}}{{21352081}} gab.com Text Susceptibility to infection and inflammatory response following influenza virus (H1N1, A/PR/8/34) challenge: role of macrophages JO: J Interferon Cytokine Res http://www.kidney.de/pget.php?&tw=1&pmid=21352081 #FOAvip The precise role that macrophages play in both influenza-induced pathology and the host's cytokine-mediated response to infection remains largely unknown. We examined the effects of lung macrophage depletion on susceptibility to influenza virus (H1N1, A/PR/8/34) infection and how this relates to the inflammatory cytokine response in the lungs. ICR mice were administered 100 muL of clodronate (CL(2)MDP) or PBS-encapsulated liposomes via an intranasal route 2 days before infection. Then, mice were intranasally inoculated with influenza virus and monitored for morbidity, mortality, and symptom severity for 21 days. Additional mice were sacrificed at 2 and 5 days postinfection, and lung tissue was analyzed for viral replication and for gene expression and protein concentration of interleukin-1beta (IL-1beta), IL-6, and TNF-alpha. Macrophage depletion increased morbidity, mortality, and symptom severity (P < 0.05) and viral replication at 2 and 5 days postinfection (P < 0.05). IL-1beta, IL-6, and TNF-alpha mRNA was greater at day 2 (P < 0.05) and IL-6 and TNF-alpha was greater at day 5 postinfection (P < 0.05) in macrophage depleted mice. Macrophage depletion increased protein concentration of IL-1beta and IL-6 at day 2 postinfection (P < 0.05). These data suggest that macrophages play a necessary role in controlling susceptibility to influenza virus and the host's cytokine-mediated response to influenza infection. Twit Text FOAVip Susceptibility to infection and inflammatory response following influenza virus (H1N1, A/PR/8/34) challenge: role of macrophages ????J Interferon Cytokine Res http://www.kidney.de/pget.php?&tw=1&pmid=21352081 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21352081 #FOAvip English Wikipedia <ref>{{Cite pmid|21352081}}</ref> Susceptibility to infection and inflammatory response following influenza virus (H1N1, A/PR/8/34) challenge: role of macrophages #MMPMID21352081 Murphy EA; Davis JM; McClellan JL; Carmichael MD; Rooijen NV; Gangemi JD J Interferon Cytokine Res 2011[Jun]; 31 (6): 501-8 PMID21352081show ga The precise role that macrophages play in both influenza-induced pathology and the host's cytokine-mediated response to infection remains largely unknown. We examined the effects of lung macrophage depletion on susceptibility to influenza virus (H1N1, A/PR/8/34) infection and how this relates to the inflammatory cytokine response in the lungs. ICR mice were administered 100 muL of clodronate (CL(2)MDP) or PBS-encapsulated liposomes via an intranasal route 2 days before infection. Then, mice were intranasally inoculated with influenza virus and monitored for morbidity, mortality, and symptom severity for 21 days. Additional mice were sacrificed at 2 and 5 days postinfection, and lung tissue was analyzed for viral replication and for gene expression and protein concentration of interleukin-1beta (IL-1beta), IL-6, and TNF-alpha. Macrophage depletion increased morbidity, mortality, and symptom severity (P < 0.05) and viral replication at 2 and 5 days postinfection (P < 0.05). IL-1beta, IL-6, and TNF-alpha mRNA was greater at day 2 (P < 0.05) and IL-6 and TNF-alpha was greater at day 5 postinfection (P < 0.05) in macrophage depleted mice. Macrophage depletion increased protein concentration of IL-1beta and IL-6 at day 2 postinfection (P < 0.05). These data suggest that macrophages play a necessary role in controlling susceptibility to influenza virus and the host's cytokine-mediated response to influenza infection. |Animals[MESH] |Blood Component Removal[MESH] |Clodronic Acid/administration & dosage/metabolism[MESH] |Cytokines/genetics/immunology/metabolism[MESH] |Disease Models, Animal[MESH] |Disease Progression[MESH] |Disease Susceptibility[MESH] |Humans[MESH] |Inflammation Mediators/immunology/metabolism[MESH] |Influenza A Virus, H1N1 Subtype/pathogenicity/*physiology[MESH] |Influenza, Human/*immunology/virology[MESH] |Lung/pathology[MESH] |Macrophages, Alveolar/drug effects/immunology/*metabolism/pathology/virology[MESH] |Mice[MESH] |Mice, Inbred ICR[MESH] |Orthomyxoviridae Infections/*immunology/virology[MESH] |RNA, Viral/*analysis[MESH]Susceptibility to infection and inflammatory response following influe(epmc).pdf DeepDyve Pubget Overpricing